Results 1 to 10 of about 204,702 (299)

Neutrophil Extracellular Traps Initiate Gallstone Formation [PDF]

Immunity, 2019
The presence of gallstones (cholelithiasis) is a highly prevalent and severe disease and one of the leading causes of hospital admissions worldwide. Due to its substantial health impact, we investigated the biological mechanisms that lead to the formation and growth of gallstones.
Luis E. Muñoz, Sebastian Boeltz, Rostyslav Bilyy, Christine Schauer, Aparna Mahajan, Navena Widulin, Anika Grüneboom, Irmgard Herrmann, Edgyda Boada, Manfred Rauh, Veit Krenn, Mona H.C. Biermann, Malgorzata J. Podolska, Jonas Hahn, Jasmin Knopf, Christian Maueröder, Solomiya Paryzhak, Tetiana Dumych, Yi Zhao, Markus F. Neurath, Markus H. Hoffmann, Tobias A. Fuchs, Moritz Leppkes, Georg Schett, Martin Herrmann   +24 more
openaire   +3 more sources

Genomic and Transcriptomic Analyses Revealed DdSTE2 Play a Role in Constricting Ring Formation in the Nematode-Trapping Fungi Drechslerella dactyloides

Microorganisms
The carnivorous fungus Drechslerella dactyloides can form constricting rings through hyphal specialization to capture nematodes. The formation of constricting rings is a prerequisite for capturing nematodes and a characteristic of entering the ...
Cheng-Lin Wu, Ren-Qiao Wang, Jin-Ting Yang, Jia-Mei Sun, Yan-Rui Xu, Jianping Xu, Ke-Qin Zhang, Lian-Ming Liang   +7 more
doaj   +1 more source

Statins Enhance Formation of Phagocyte Extracellular Traps [PDF]

Cell Host & Microbe, 2010
Statins are inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthesis. Recent clinico-epidemiologic studies correlate patients receiving statin therapy with having reduced mortality associated with severe bacterial infection.
Chow, O A, von Köckritz-Blickwede, M, Bright, A T, Hensler, M E, Zinkernagel, A S, Cogen, A L, Gallo, R L, Monestier, M, Wang, Y, Glass, C K, Nizet, V   +10 more
openaire   +3 more sources

Pneumolysin activates neutrophil extracellular trap formation [PDF]

Clinical and Experimental Immunology, 2016
Summary The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils were exposed to recombinant Ply (5-20 ng ml−1) for 30–90 min at 37°C and NET formation measured using the ...
Nel, Jan Gert, Theron, Annette J., Durandt, Chrisna, Tintinger, Gregory Ronald, Pool, Roger, Mitchell, Timothy J., Feldman, Charles, Anderson, Ronald   +7 more
openaire   +3 more sources

Histone Acetylation Promotes Neutrophil Extracellular Trap Formation

Biomolecules, 2019
Neutrophils undergo a unique form of cell death to generate neutrophil extracellular traps (NETs). It is well established that citrullination of histones (e.g., CitH3) facilitates chromatin decondensation during NET formation (NETosis), particularly ...
Hussein J. Hamam, Meraj A. Khan, Nades Palaniyar   +2 more
doaj   +1 more source

Rac2 is required for the formation of neutrophil extracellular traps [PDF]

Journal of Leukocyte Biology, 2011
ABSTRACTNeutrophils play a critical role as a first line of defense against invading pathogens. Recently, a new defense strategy of neutrophils was described, in which pathogens are trapped and killed by NETs. However, the exact underlying mechanisms leading to the formation of NETs remain elusive. Here, we explored the role of the Rac small GTPases in
Lim, MB, Kuiper, JB, Katchky, A, Goldberg, H, Glogauer, Michael   +4 more
openaire   +3 more sources

On the mechanism of trapped surface formation

, 1993
By a combination of analytical and numerical methods, the density profile of a momentarily at rest spherical star is varied, and the corresponding response in the area of the spherical shells is monitored. It is shown that the inner apparent horizon (if it exists) must lie within or at most on the star's surface, while no such restriction is found for ...
Valls-Gabaud, David, Zannias, Thomas
openaire   +2 more sources

Cathepsin K regulates localization and secretion of Tartrate-Resistant Acid Phosphatase (TRAP) in TRAP-overexpressing MDA-MB-231 breast cancer cells

BMC Molecular and Cell Biology, 2020
Background Tartrate–resistant acid phosphatase (TRAP/ ACP5) belongs to the binuclear metallophosphatase family and is present in two isoforms. The primary translation product is an uncleaved TRAP 5a isoform with low phosphatase activity.
Anja Reithmeier, Maria Norgård, Barbro Ek-Rylander, Tuomas Näreoja, Göran Andersson   +4 more
doaj   +1 more source

Inhibition of Peptidyl Arginine Deiminase-4 Prevents Renal Ischemia-Reperfusion-Induced Remote Lung Injury

Mediators of Inflammation, 2020
Ischemia reperfusion (IR) can lead to acute kidney injury and can be complicated by acute lung injury, which is one of the leading causes of acute kidney injury-related death.
Mingjun Du, Lei Yang, Jianmin Gu, Jiawei Wu, Yiwen Ma, Tao Wang   +5 more
doaj   +1 more source

DhSip1, an NRPS-independent siderophore biosynthetic gene, regulates adhesive knob formation and pathogenicity in Dactylellina haptotyla through mediating iron acquisition

Applied and Environmental Microbiology
Iron acquisition plays a crucial role in fungal pathogenicity. Nematode-trapping fungi (NTFs) serve as important biocontrol agents that can develop traps to capture and kill nematodes.
Hong-Mei Lei, Shi-Mei Shen, Ping Xu, Guo-Hong Li, Pei-Ji Zhao   +4 more
doaj   +1 more source