Results 91 to 100 of about 615,852 (293)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
BMC Molecular and Cell Biology, 2020 Background Tartrate–resistant acid phosphatase (TRAP/ ACP5) belongs to the binuclear metallophosphatase family and is present in two isoforms. The primary translation product is an uncleaved TRAP 5a isoform with low phosphatase activity.
Anja Reithmeier +4 more
doaj +1 more source
Nano Select, 2022 Scaffolds capable of inducing ectopic osteogenesis (i.e., osteoinduction) have the potential to treat congenital and massive bone defects. However, the mechanisms underlying osteoinduction remain elusive, largely because of rapid tissue changes occurring
Koichiro Hayashi, Kunio Ishikawa
doaj +1 more source
Waveguides for Rydberg excitons in Cu$_\text{2}$O from strain traps
, 2018 We investigate the formation of waveguides for Rydberg excitons in Cu$_\text{2}$O from cylindrical stressors as alternatives to optical traps. We show that the achievable potential depths can easily reach the meV and the trap frequencies the GHz regimes.
Krüger, Sjard Ole, Scheel, Stefan
core +1 more source
Dynamics of F=1 87Rb condensates at finite temperatures [PDF]
, 2006 We investigate the dynamics of a F=1 spinor Bose-Einstein condensate of 87Rb atoms confined in a quasi-one-dimensional trap both at zero and at finite temperature.
Bongs, Kai +6 more
core +3 more sources
Nontrivial Haldane phase of an atomic two-component Fermi gas trapped in a 1d optical lattice
, 2012 We propose how to create a non-trivial Haldane phase in atomic two-component Fermi-gas loaded on one-dimensional (1-D) optical lattice with trap potential.
Kobayashi, Keita +4 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Mediators of Inflammation, 2020 Ischemia reperfusion (IR) can lead to acute kidney injury and can be complicated by acute lung injury, which is one of the leading causes of acute kidney injury-related death.
Mingjun Du +5 more
doaj +1 more source