Results 81 to 90 of about 204,702 (299)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

AoMbp1 Governs Conidiation and Trap Morphogenesis in Arthrobotrys oligospora Via Direct Transcriptional Activation of the MAPK Sensor AoSho1

Journal of Fungi
The nematode-trapping fungus (NTF) Arthrobotrys oligospora (A. oligospora) is a promising biocontrol agent, but the transcriptional regulators governing its predation remain poorly understood.
Ruobing Li, Lixiang Wei, Yanseng Sun, Chengzhi Zhang, Yuhang Nie, Qinglong Meng, Shuang Chen, Ming Wu, Xuepeng Cai, Jie Li, Qingling Meng, Jun Qiao   +11 more
doaj   +1 more source

Formation fluid characteristics and hydrocarbon accumulation in the Dongying sag, Shengli Oilfield

Petroleum Exploration and Development, 2012
Based on the analysis of geochemical characteristics and distribution of different formation waters, a new origin identification standard was established for the formation water in the Paleogene Shahejie Formation in the Dongying Sag. The migration paths
Shanwen ZHANG, Linye ZHANG, Youshu BAO, Xiaoyan LI, Qing LIU, Juyuan LI, Yan YIN, Rifang ZHU, Shouchun ZHANG   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Fluorescent Filter-Trap Assay for Amyloid Fibril Formation Kinetics in Complex Solutions.

, 2015
Amyloid fibrils are the most distinct components of the plaques associated with various neurodegenerative diseases. Kinetic studies of amyloid fibril formation shed light on the microscopic mechanisms that underlie this process as well as the ...
Irem Nasir (788932), Nasir, Irem, Celia Cabaleiro-lago, Irem Nasir, Cabaleiro-Lago, Celia, Sara Linse, Celia Cabaleiro-Lago (1328658), Linse, Sara, Sara Linse (62281)   +8 more
core   +2 more sources

The net effect of ANCA on neutrophil extracellular trap formation

, 2018
The formation of neutrophil extracellular traps induced by antineutrophil cytoplasmic autoantibodies has been implicated in the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis. Kraaij et al.
Rutgers, Abraham, Abraham Rutgers, Heeringa, Peter, Kallenberg, Cees G M, Heeringa, Peter; id_orcid, Rutgers, Abraham; id_orcid, Peter Heeringa, Cees G.M. Kallenberg   +7 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Feshbach spectroscopy of an ultracold Rb-Cs mixture [PDF]

, 2012
This thesis reports the observation of interspecies Feshbach resonances in an ultracold mixture of Rb and Cs atoms. A versatile combined magnetic and optical potential has been designed and constructed which is capable of bringing both $^{87}\rm{Rb}$ and
Jenkin, Daniel Lester, JENKIN, DANIEL,LESTER, Daniel L. Jenkin   +2 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Formation of Two-Ion Crystals by Injection from a Paul-Trap Source into a High-Magnetic-Field Penning Trap

, 2022
Two-ion crystals constitute a platform for investigations of quantum nature that can be extended to any ion species or charged particle provided one of the ions in the crystal can be directly laser-cooled and manipulated with laser radiation.
Berrocal, Joaquín, Rodríguez, Daniel, Ospelkaus, C., Altozano, Emilio, Altozano, E., Fernández, F. J., Domínguez, F., Ospelkaus, Christian, Berrocal, J., Gutiérrez, M. J., Rodríguez, D., Cerrillo, Javier, Fernández, Francisco Javier, Gutiérrez, Manuel Jesús, Block, Michael, Domínguez, Francisco, Cerrillo, J.   +16 more
core   +1 more source