Results 61 to 70 of about 4,431,538 (308)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Physical Modeling of Scale Differences in Large Subsalt Detachment Folds: A Case Study from the Eastern Kuqa Foreland Basin

Applied Sciences
This research reveals the coupling mechanism between structural deformation and hydrocarbon accumulation. The Dibei area in the Kuqa Depression represents a key hydrocarbon exploration domain within the northern Tarim foreland basin.
Zeyi Wang, Jinning Zhang, Yongxu Mei, Yanna Wu, Haodong Lin, Jiehao Su, Ke Xu, Yuchao Sun   +7 more
doaj   +1 more source

Ménage-à-trois: The ratio of bicarbonate to CO2 and the pH regulate the capacity of neutrophils to form NETs

Frontiers in Immunology, 2016
In this study we identified and characterized the potential of a high ratio of bicarbonate to CO2 and a moderately alkaline pH to render neutrophils prone to undergo neutrophil extracellular trap (NET) formation.
Christian Maueröder, Aparna Siddharth Mahajan, Susanne Paulus, Stefanie Nowecki, Jonas Hahn, Deborah Kienhöfer, Mona Helena Biermann, Philipp Tripal, Ralf Philipp Friedrich, Luis Enrique Munoz, Markus F Neurath, Christoph Becker, Georg Andreas Schett, Martin Herrmann, Moritz Leppkes   +14 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Pneumolysin activates neutrophil extracellular trap formation [PDF]

Clinical and Experimental Immunology, 2016
Summary The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils were exposed to recombinant Ply (5-20 ng ml−1) for 30–90 min at 37°C and NET formation measured using the ...
Nel, Jan Gert, Theron, Annette J., Durandt, Chrisna, Tintinger, Gregory Ronald, Pool, Roger, Mitchell, Timothy J., Feldman, Charles, Anderson, Ronald   +7 more
openaire   +3 more sources

A mechanical insect trap [PDF]

, 1935
In the course of some work at Rothamsted on the activity and abundance of insects, in which a light trap was used as a method of estimating the numbers of insects in a state of activity, it appeared advisable to have a further trapping method which did ...
Williams, C. B., Milne, P. S.
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Genomic and Transcriptomic Analyses Revealed DdSTE2 Play a Role in Constricting Ring Formation in the Nematode-Trapping Fungi Drechslerella dactyloides

Microorganisms
The carnivorous fungus Drechslerella dactyloides can form constricting rings through hyphal specialization to capture nematodes. The formation of constricting rings is a prerequisite for capturing nematodes and a characteristic of entering the ...
Cheng-Lin Wu, Ren-Qiao Wang, Jin-Ting Yang, Jia-Mei Sun, Yan-Rui Xu, Jianping Xu, Ke-Qin Zhang, Lian-Ming Liang   +7 more
doaj   +1 more source