Results 51 to 60 of about 371,582 (273)

Eye movement desensitisation and reprocessing for offence-related trauma in a mentally disordered sexual offender [PDF]

, 2014
Research demonstrates a high incidence of offence-related trauma in mentally disordered offenders convicted of violent and sexual offences. The adaptive information processing (AIP) model offers a theoretical framework for understanding the hypothesised ...
Gannon, Theresa A., Kingham, Michael, Tyler, Nichola, Clark, Lauren   +3 more
core   +1 more source

The MET(T)A Protocol: Mindfulness and EMDR Treatment Template for Agencies

Substance Abuse: Research and Treatment, 2020
Evidence indicating the relationship between trauma and substance use disorders (SUDs), in addition to relapse and treatment retention rates for this population, suggests there is a need for a trauma-focused solution to treat SUDs.
Stephen Dansiger, Roshni Chabra, Lauren Emmel, Justine Kovacs   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Evaluation of the feasibility and effectiveness of trauma-focused cognitive behavioural therapy for children and youth in Ukraine during the war

European Psychiatry
Background The large-scale Russian invasion of Ukraine in early 2022 resulted in a humanitarian crisis with hundreds of thousands of children exposed to traumatic events.
Elisa Pfeiffer, Maike Garbade, Renée Beer, Anette Birgersson, Natalie Cabrera, Judith A. Cohen, Esther Deblinger, Rafaela Gjini, Veronica Kirsch, Zlatina Kostova, Michael Larsson, Anthony Mannarino, Gavin Moffitt, Marja Onsjö, Tale Ostensjo, Anna Vikgren, Hanna Weyler, Vitalii Klymchuk, Cedric Sachser   +18 more
doaj   +1 more source

Challenges in treatment of posttraumatic stress disorder in refugees: towards integration of evidence-based treatments with contextual and culture-sensitive perspectives [PDF]

European Journal of Psychotraumatology, 2015
Background: Research shows that trauma-focused therapy and multimodal interventions are the two most often used strategies in treatment of refugees suffering from posttraumatic stress disorder (PTSD).
Boris Drožđek
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Successful treatment of a combined bronchial and aortic trauma

, 2020
Tracheobronchial injury is an uncommon but severe complication of blunt thoracic trauma. In this study, we present a patient who developed complete avulsion of the left main bronchus with a vertical rupture toward the carina accompanying a contained ...
Saricam, Murat, Ozkan, Berker, Sarıçam, Murat, Toker, Alper   +3 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Predicting Trauma-Focused Therapy Outcome From Resting-State Functional Magnetic Resonance Imaging in Veterans With Posttraumatic Stress Disorder

, 2018
Background Trauma-focused psychotherapy is the first-line treatment for posttraumatic stress disorder (PTSD) but 30-50% of patients do not benefit sufficiently.
Miranda Olff, Geuze, E., Olff, Miranda, Paul Zhutovsky, Elbert Geuze, Varkevisser, Tim, Thomas, R., Kennis, M., Trauma and Grief, Tim Varkevisser, Thomas, Rajat, Leerstoel Boelen, Zhutovsky, P., Zhutovsky, Paul, Sanne J.H. van Rooij, Geuze, Elbert, Varkevisser, T., Guido van Wingen, Olff, M., Rajat Thomas, van Wingen, Guido, van Rooij, Sanne J. H., van Wingen, G.A., van Rooij, S.J.H., Mitzy Kennis, Kennis, Mitzy   +25 more
core   +1 more source