Results 61 to 70 of about 371,582 (273)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sudden gains in routine clinical care: application of a permutation test for trauma-focused cognitive behavioural therapy

European Journal of Psychotraumatology
Background: Sudden gains, defined as large and stable improvements of psychopathological symptoms, are a ubiquitous phenomenon in psychotherapy. They have been shown to occur across several clinical contexts and to be associated with better short-term ...
Sascha Kuck, Thomas Ehring, Anne Dyer, Andre Pittig, Jana Peikenkamp, Nexhmedin Morina, Georg W. Alpers, Antje Krüger-Gottschalk   +7 more
doaj   +1 more source

Parent-led stepped care for traumatised children: parental factors that predict treatment completion and response

European Journal of Psychotraumatology, 2023
Background: Stepped care cognitive behavioural therapy for children after trauma (SC-CBT-CT; aged 7–12 years) can help to increase access to evidence-based trauma treatments for children.
Else Merete Fagermoen, Ingeborg Skjærvø, Tine K. Jensen, Silje Mørup Ormhaug   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The bumpy road of trauma‐focused treatment: Posttraumatic stress disorder symptom exacerbation in people with psychosis

Journal of Traumatic Stress, 2023
AbstractConcern for symptom exacerbation and treatment drop‐out is an important barrier to the implementation of trauma‐focused therapy (TFT), especially in people with a psychotic disorder. This study, which was part of a multicenter randomized controlled trial, investigated posttraumatic stress disorder (PTSD) symptom exacerbation during eye movement
Simone R. Burger, Amy Hardy, Tineke van der Linden, Catherine van Zelst, Paul A. J. de Bont, Berber van der Vleugel, Anton B. P. Staring, Carlijn de Roos, Ad de Jongh, Machteld Marcelis, Agnes van Minnen, Mark van der Gaag, David P. G. van den Berg   +12 more
openaire   +6 more sources

Outcomes and costs of penetrating trauma injury in England and Wales

, 2008
The official published version of the article can be found at the link below.Background: Penetrating trauma injury is generally associated with higher short-term mortality than blunt trauma, and results in substantial societal costs given the young age ...
Morris, S, Nielsen, TG, Ridley, S, Christensen, MC, Lecky, FE   +4 more
core   +1 more source

Treatment of multiple traumatized adolescents by enhancing regulation skills and reducing trauma related symptoms: rationale, study design, and methods of randomized controlled trial (the Mars-study)

BMC Psychiatry, 2023
Background There is ongoing debate regarding the treatment of severe and multiple traumatized children and adolescents with post-traumatic stress disorder (PTSD).
Rik Knipschild, Helen Klip, Doenja van Leeuwaarden, Mariken J. R. van Onna, Ramon J. L. Lindauer, Wouter G. Staal, Iva A. E. Bicanic, Ad de Jongh   +7 more
doaj   +1 more source

Case Report: Infra-Low-Frequency Neurofeedback for PTSD: A Therapist's Perspective

Frontiers in Human Neuroscience, 2022
The practical use of a combination of trauma psychotherapy and neurofeedback [infra-low-frequency (ILF) neurofeedback and alpha-theta training] is described for the treatment of patients diagnosed with complex post-traumatic stress disorder (C-PTSD). The
Regula Spreyermann
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source