Results 71 to 80 of about 371,582 (273)

Trauma-Focused Treatment in PTSD Patients With Psychosis: Symptom Exacerbation, Adverse Events, and Revictimization. [PDF]

Schizophr Bull, 2016
Most clinicians refrain from trauma treatment for patients with psychosis because they fear symptom exacerbation and relapse. This study examined the negative side effects of trauma-focused (TF) treatment in patients with psychosis and posttraumatic stress disorder (PTSD).Analyses were conducted on data from a single-blind randomized controlled trial ...
van den Berg DP, de Bont PA, van der Vleugel BM, de Roos C, de Jongh A, van Minnen A, van der Gaag M.   +6 more
europepmc   +7 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Trauma-informed services and trauma-specific care for Indigenous Australian children [PDF]

, 2013
This paper examines how childhood trauma experienced by Indigenous children can be overcome by appropriate interventions.IntroductionWhile many Indigenous and non-Indigenous Australian children grow up in safe homes and live in safe communities, there ...
Judy Atkinson
core  

A systematic review and meta-analysis of psychological interventions for comorbid post-traumatic stress disorder and substance use disorder

European Journal of Psychotraumatology, 2022
Background The psychological treatment of comorbid post-traumatic stress disorder (PTSD) and substance use disorder (SUD) is clinically challenging, and outcomes are often poor.
Neil P. Roberts, Annett Lotzin, Ingo Schäfer   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Seven-Year Follow-Up Study of Symptoms in Asylum Seekers and Refugees With PTSD Treated With Trauma-Focused Groups.

, 2014
OBJECTIVE: To examine sustainability of symptom outcomes of a 1-year phase-based trauma-focused, multimodal, and multicomponent group therapy in a day treatment program for posttraumatic stress disorder (PTSD) over an average period of 7 years.
Knipscheer, Jeroen, Leerstoel Bout, Kamperman, Astrid, Drozdek, B, Kleber, RJ, Kamperman, Astrid; id_orcid, Kamperman, A.M., Knipscheer, JW, Drožđek, B, Tol, W.A., Trauma and Grief, Tol, WA, Kleber, Rolf, Leerstoel Kleber   +13 more
core   +1 more source

Treating hoarding disorder with compassion‐focused therapy: A pilot study examining treatment feasibility, acceptability, and exploring treatment effects [PDF]

, 2019
ObjectivesHoarding disorder (HD) was recognized as a psychiatric disorder in 2013. Existing literature suggests room for improvement in its treatment. The current pilot study aimed to provide an initial evaluation on the potential of compassion-focused ...
Chan, Joanne, Smith, Lauren C, Tsoh, Janice Y, Joanne Chan, Chou, Chia-Ying, Smith, Lauren C., Carol A. Mathews, Gilbert, Paul, Chou, Chia‐Ying, Kevin Delucchi, Shumway, Martha, Tirch, Dennis, Mathews, Carol A, Chia‐Ying Chou, Paul Gilbert, Janice Y. Tsoh, Martha Shumway, Dennis Tirch, Mathews, Carol A., Tsoh, Janice Y., Delucchi, Kevin, Lauren C. Smith   +21 more
core   +1 more source

The COVID Shift: Comparing Hybrid Telehealth to In-Person Group Therapy for Incarcerated Women Survivors of Sexual Violence Victimization

Social Sciences
Incarcerated women report extremely high rates of lifetime sexual violence victimization. Survivors Healing from Abuse: Recovery through Exposure (SHARE) is an exposure-based group therapy specifically designed for incarcerated women survivors of sexual ...
Ana J. Bridges, Marley F. Fradley, Ayla R. Mapes, Roselee J. Ledesma, Emily L. Allen, Marie E. Karlsson, Melissa J. Zielinski   +6 more
doaj   +1 more source