Results 31 to 40 of about 576,536 (299)

The synapse in traumatic brain injury

Brain : a journal of neurology, 2020
Traumatic brain injury is a leading cause of death and disability and is a risk factor for dementia later in life. Jamjoom et al. review the role of the synapse in TBI pathophysiology with a focus on the confluence of secondary injury processes including
A. Jamjoom, J. Rhodes, P. Andrews, S. Grant   +3 more
semanticscholar   +1 more source

A randomized controlled trial protocol for people with traumatic brain injury enrolled in a healthy lifestyle program (GLB-TBI)

Contemporary Clinical Trials Communications, 2019
Weight gain is prevalent among people with traumatic brain injury (TBI) and may be attributable to environmental or injury-specific factors such as mobility impairment, endocrine dysfunction, behavioral and emotional disorders, and sensory loss.
Simon Driver, Shannon Juengst, Evan Elizabeth McShan, Monica Bennett, Kathleen Bell, Rosemary Dubiel   +5 more
doaj   +1 more source

Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study.

JAMA Neurology, 2019
Importance Most traumatic brain injuries (TBIs) are classified as mild (mTBI) based on admission Glasgow Coma Scale (GCS) scores of 13 to 15. The prevalence of persistent functional limitations for these patients is unclear.
L. Nelson, N. Temkin, S. Dikmen, Jason Barber, J. Giacino, E. Yuh, H. Levin, M. McCrea, M. Stein, P. Mukherjee, D. Okonkwo, R. Diaz-Arrastia, G. Manley, O. Adeoye, N. Badjatia, Kim Boase, Yelena G. Bodien, M. Bullock, R. Chesnut, J. Corrigan, K. Crawford, A. Duhaime, R. Ellenbogen, V. Feeser, Adam R Ferguson, B. Foreman, Raquel C Gardner, É. Gaudette, Luis Gonzalez, S. Gopinath, R. Gullapalli, J. Hemphill, G. Hotz, Sonia Jain, F. Korley, J. Kramer, Natalie P. Kreitzer, C. Lindsell, J. Machamer, C. Madden, Alastair J. Martin, T. McAllister, Randall E. Merchant, Florence Noel, E. Palacios, D. Perl, A. Puccio, Miri Rabinowitz, C. Robertson, J. Rosand, A. Sander, G. Satris, David M Schnyer, S. Seabury, M. Sherer, Sabrina R. Taylor, A. Toga, A. Valadka, M. Vassar, P. Vespa, Kevin K. W. Wang, J. Yue, R. Zafonte   +62 more
semanticscholar   +1 more source

Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice

British Journal of Pharmacology, 2020
Oxidative stress and neuronal apoptosis play key roles in traumatic brain injury. We investigated the protective effects of astaxanthin against traumatic brain injury and its underlying mechanisms of action.
Xiang-Sheng Zhang, Yue Lu, Wen Li, Tao Tao, Lei Peng, Wei‐Han Wang, Sen Gao, Cang Liu, Zhuang Zong, Dayong Xia, C. Hang, Wei Li   +11 more
semanticscholar   +1 more source

An Objective Assessment of Neuromotor Control Using a Smartphone App After Repeated Subconcussive Blast Exposure

Sensors
Subconcussive blast exposure has been shown to alter neurological functioning. However, the extent to which neurological dysfunction persists after blast exposure is unknown.
Charlend K. Howard, Masahiro Yamada, Marcia Dovel, Rie Leverett, Alexander Hill, Kenneth A. Manlapaz, David O. Keyser, Rene S. Hernandez, Sheilah S. Rowe, Walter S. Carr, Michael J. Roy, Christopher K. Rhea   +11 more
doaj   +1 more source

Nurses’ contribution to relatives’ involvement in neurorehabilitation: Facilitators and barriers

Nursing Open, 2019
Aim The aim of the present study was to identify possible facilitators and barriers that differently positioned relatives are facing when being actively involved in the rehabilitation process of patients with traumatic brain injury.
Rikke Guldager, Karen Willis, Kristian Larsen, Ingrid Poulsen   +3 more
doaj   +1 more source

Unravelling the current shortfalls, challenges, and opportunities in traumatic brain injury

BMC Neurology, 2023
The brain is the control centre of the human body. Injury to the brain can have diverse and disabling effects. Yet there remain important unanswered questions for clinicians, those affected and their families.
A. Theadom, N. Andelic, V. Chavda, M. Pedersen   +3 more
doaj   +1 more source

Diffuse axonal injury predicts neurodegeneration after moderate-severe traumatic brain injury.

Brain : a journal of neurology, 2020
Traumatic brain injury is associated with elevated rates of neurodegenerative diseases such as Alzheimer's disease and chronic traumatic encephalopathy. In experimental models, diffuse axonal injury triggers post-traumatic neurodegeneration, with axonal ...
Neil S N Graham, Amy E. Jolly, K. Zimmerman, N. Bourke, G. Scott, J. Cole, J. Schott, D. Sharp   +7 more
semanticscholar   +1 more source

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source