Results 61 to 70 of about 824,886 (383)

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

Nature Communications, 2019
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and ...
Ashley C. Bolte, A. Dutta, Mariah E. Hurt, Igor Smirnov, M. Kovacs, Celia A. McKee, Hannah E Ennerfelt, Daniel A. Shapiro, Bao H. Nguyen, Elizabeth L. Frost, Catherine R. Lammert, J. Kipnis, J. Lukens   +12 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Facilitating return to work through early specialist health-based interventions (FRESH): protocol for a feasibility randomised controlled trial [PDF]

, 2015
Background Over one million people sustain traumatic brain injury each year in the UK and more than 10 % of these are moderate or severe injuries, resulting in cognitive and psychological problems that affect the ability to work.
A Franulic, A Relyea-Chew, A Tyerman, AH Briggs, AH Willemse-van Son, AM Salazar, AS Zigmond, B Robinson, B Willer, British Society of Rehabilitation Medicine, E Rickels, F Nouri, J Langley, J Phillips, J Possl, JK Fadyl, JM Velzen Van, JM Velzen van, JN Horton, KA Radford, LE Trexler, MC Reilly, P Deshpande, R Brooks, RD Vanderploeg, S Schonbrun, T Ownsworth   +26 more
core   +5 more sources

Targeted Perfusion Therapy in Spinal Cord Trauma. [PDF]

, 2020
We review state-of-the-art monitoring techniques for acute, severe traumatic spinal cord injury (TSCI) to facilitate targeted perfusion of the injured cord rather than applying universal mean arterial pressure targets.
Papadopoulos, MC, Saadoun, S
core   +1 more source

Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice

British Journal of Pharmacology, 2020
Oxidative stress and neuronal apoptosis play key roles in traumatic brain injury. We investigated the protective effects of astaxanthin against traumatic brain injury and its underlying mechanisms of action.
Xiang-Sheng Zhang, Yue Lu, Wen Li, Tao Tao, Lei Peng, Wei‐Han Wang, Sen Gao, Cang Liu, Zhuang Zong, Dayong Xia, C. Hang, Wei Li   +11 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Severe Traumatic Brain Injury [PDF]

Neurosurgery, 2017
Background: Inadvertent hyperventilation is associated with poor outcomes from traumatic brain injury (TBI). Hypocapnic cerebral vasoconstriction is well described and causes an immediate and profound decrease in cerebral perfusion. The hemodynamic effects of positive-pressure ventilation (PPV) remain incompletely understood but may be equally ...
David L, Penn, John H, Chi, Mark R, Proctor   +2 more
openaire   +2 more sources

Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study.

JAMA Neurology, 2019
Importance Most traumatic brain injuries (TBIs) are classified as mild (mTBI) based on admission Glasgow Coma Scale (GCS) scores of 13 to 15. The prevalence of persistent functional limitations for these patients is unclear.
L. Nelson, N. Temkin, S. Dikmen, Jason Barber, J. Giacino, E. Yuh, H. Levin, M. McCrea, M. Stein, P. Mukherjee, D. Okonkwo, R. Diaz-Arrastia, G. Manley, O. Adeoye, N. Badjatia, Kim Boase, Yelena G. Bodien, M. Bullock, R. Chesnut, J. Corrigan, K. Crawford, A. Duhaime, R. Ellenbogen, V. Feeser, Adam R Ferguson, B. Foreman, Raquel C Gardner, É. Gaudette, Luis Gonzalez, S. Gopinath, R. Gullapalli, J. Hemphill, G. Hotz, Sonia Jain, F. Korley, J. Kramer, Natalie P. Kreitzer, C. Lindsell, J. Machamer, C. Madden, Alastair J. Martin, T. McAllister, Randall E. Merchant, Florence Noel, E. Palacios, D. Perl, A. Puccio, Miri Rabinowitz, C. Robertson, J. Rosand, A. Sander, G. Satris, David M Schnyer, S. Seabury, M. Sherer, Sabrina R. Taylor, A. Toga, A. Valadka, M. Vassar, P. Vespa, Kevin K. W. Wang, J. Yue, R. Zafonte   +62 more
semanticscholar   +1 more source

Diffuse axonal injury predicts neurodegeneration after moderate-severe traumatic brain injury.

Brain : a journal of neurology, 2020
Traumatic brain injury is associated with elevated rates of neurodegenerative diseases such as Alzheimer's disease and chronic traumatic encephalopathy. In experimental models, diffuse axonal injury triggers post-traumatic neurodegeneration, with axonal ...
Neil S N Graham, Amy E. Jolly, K. Zimmerman, N. Bourke, G. Scott, J. Cole, J. Schott, D. Sharp   +7 more
semanticscholar   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source