ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Importance of Being Early [PDF]
The assumption that the penalty for being early is less than that for being late was put forward by Vickrey (1963) who analyzed how commuters compare penalties in the form of schedule delay (due to peak hour congestion), against penalties in the form of ...
Anupam Srivastava +3 more
core
Domestic travel behaviour among Generation Y / Farhan Faat, Nurul Hazirah Mohd Nasir and Nik Mohd Shahril Nik Mohd Nor [PDF]
, 2017 Youth travelers normally have a limited budget in exploring new destinations. Despite having a high curiosity and relaxation time, it has been found that youth travelers have high assumptions with respect to the significance of quality for cash they ...
Faat, Farhan +2 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Impact of COVID-19 on adolescent travel behavior. [PDF]
J Transp Health, 2022 Liu J, Cao Q, Pei M.
europepmc +1 more source
Demand for Vacations /Travel in Protected Areas – Dimension of Tourists’ Ecological Behavior [PDF]
Tourism, in itself, is one of the main users of the environment and, implicitly, an important contributor to its deterioration. Intensification of tourist travel will naturally generate an increase of the negative environmental impacts and, in the long ...
Delia Popescu +3 more
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Journal of Transport and Land UseThe impacts of transit-oriented development (TOD) on travel behavior have been extensively studied, with a predominant focus on cross-sectional analyses that provide a static evaluation at a specific point in time by comparing TODs and non-TODs ...
Bin Chi, Jinwoo Lee
doaj +1 more source
Validity and reliability of short-form travel behavior questionnaire during COVID-19 pandemic (TBQ-Cov19). [PDF]
J Transp Health, 2023 Rezaei M +13 more
europepmc +1 more source