Results 81 to 90 of about 1,167,337 (295)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Evidence-based practices in sustainable travel behavior intervention: A knowledge graph-based systematic review

Journal of Traffic and Transportation Engineering (English ed. Online)
Sustainable travel behavior intervention is an essential strategy to promote the development of urban transportation. The interventions offer personalized strategies based on certain scenario and participants to promote its effectiveness over hard travel
Jian Li, Chenjie Xu
doaj   +1 more source

Information, communication, travel behavior and accessibility

Journal of Transport and Land Use, 2013
Over the past two decades many papers have been published on the impact of Information and Communication Technologies (ICT) on travel behavior, but the literature focusing on the impact of ICT on accessibility is relatively scarce.
Bert van Wee, Karst Geurs, Caspar Chorus
doaj   +1 more source

Socio-demographic constraints to travel behavior

, 2009
Purpose – This study aims to ascertain the effect of socio-demographic constraints on dimension of travel choice. This study also seeks to derive personal ecological explanations for variation in travel preference, travel intention and travel ...
Kattiyapornpong, Uraiporn, Miller, Kenneth   +1 more
core   +1 more source

Role of Dispositional Aspects of Self-identity in the Process of Planned Behavior of Outbound Travel [PDF]

, 2017
Identity theorists suggest that one’s self-identity affects his behavioral intent directly, while planned behavior researchers believe that one’s attitude toward a specific behavior has a direct effect on his intention to perform the behavior.
Lee, Soonhwan, Wang, Suosheng, Wu, Lingfei   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Disruptions to Transportation Networks: A Review [PDF]

Travel decisions may be very stable in a familiar environment. Major network disruptions such as the I-35W bridge collapse disrupt habitual behavior. Such ``natural'' experiments provide unique opportunities for behavioral studies, but the time window ...
David Levinson, Shanjiang Zhu
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

How Do Information Interventions Influence Walking and Cycling Behavior?

Buildings
In the context of promoting sustainable mobility, walking and cycling have been widely recognized for their environmental and health benefits. However, a notable gap often exists between residents’ motivation to engage in these modes and their actual ...
Wenxuan Lu, Lan Wu, Chaoying Yin, Ming Yang, Qiyuan Yang, Xiaoyi Zhang   +5 more
doaj   +1 more source