Results 91 to 100 of about 213,940 (301)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Overseas pleasure travel motivations of older alumnae of a Japanese women's university [PDF]

open access: yes, 2002
Plan BThis study examined overseas pleasure travel motivations of Tsuda College (a women’s university in Tokyo, Japan) older alumnae, whose approximate ages ranged from 55 to 79 years old.
Takaya, Sachiko
core  

Investigating changes in travel behavior over time in response to the COVID-19 pandemic. [PDF]

open access: yesTransp Res Part F Traffic Psychol Behav, 2023
Rostami A   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Behavioral calibration of a large-scale travel behavior microsimulation [PDF]

open access: yes
This article reports on the application and calibration of a fully disaggregate (agent-based) transport simulation for the metropolitan area of Zurich. The application of a novel calibration technique yields cross-validation results that are competitive ...
Nagel, Kai   +3 more
core  

Assessing the long-term impact of COVID-19 on travel behavior: The United Arab Emirates perspective

open access: yesTransportation Research Interdisciplinary Perspectives
The unprecedented COVID-19 pandemic has caused significant short-term travel disruptions and profound changes in daily travel routines. Yet, the long-term impact on travel behavior and mobility remains unclear.
Khaled Hamad   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Trends in commuter and leisure travel in The Netherlands 1991-2001 - Mode choice and travel time [PDF]

open access: yes
Data collected over recent years indicates that there has been an increase in the average distance of trips made, in the Netherlands (e.g. in 1985 the average trip made was 8.7 km, in 2000 the average trip length was 10.6 km (Harms, 2003)).
Christy Collins, Arianne De Blaeij
core  

Barriers To Gender-Based Pro-Environmental Travel Behavior

open access: yes
This chapter aims to rationally analyze responsible travel behavior from the sustainability and development perspective, indicating barriers and implications toward tourists’ pro-environmental behavior.
Kozak, M., Chalermchaikit, V.
core   +1 more source

QUALITATIVE RESEARCH IN TRAVEL BEHAVIOR STUDIES

open access: yesLibro de Actas CIT2016. XII Congreso de Ingeniería del Transporte, 2016
Qualitative methodology is extensively used in a wide range of scientific areas, such as Sociology and Psychology, and it is been used to study individual and household decision making processes. However, in the Transportation Planning and Engineering domain it is still infrequent to find in the travel behavior literature studies using qualitative ...
Mars Aicart, María del Lidón   +2 more
openaire   +5 more sources

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