Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Value of Travel Time Reliability: A review of current evidence [PDF]
Travel time reliability is a fundamental factor in travel behavior. It represents the temporal uncertainty experienced by users in their movement between any two nodes in a network. The importance of the time reliability depends on the penalties incurred
Carlos Carrion, David Levinson
core
The Intersection of Urban Form and Mileage Fees: Findings from the Oregon Road User Fee Pilot Program, Research Report 10-04 [PDF]
, 2011 This report analyzes data from the 2006-2007 Oregon Road User Fee Pilot program to assess if and how urban form variables correlate with travel behavior changes that participants made in response to the mileage-based fee program. It finds that charging a
Agrawal, Asha Weinstein +3 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Assessing the long-term impact of COVID-19 on travel behavior: The United Arab Emirates perspective
Transportation Research Interdisciplinary PerspectivesThe unprecedented COVID-19 pandemic has caused significant short-term travel disruptions and profound changes in daily travel routines. Yet, the long-term impact on travel behavior and mobility remains unclear.
Khaled Hamad +3 more
doaj +1 more source
Investigating changes in travel behavior over time in response to the COVID-19 pandemic. [PDF]
Transp Res Part F Traffic Psychol Behav, 2023 Rostami A +5 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Journal of Advanced Transportation, 2019 Household traffic surveys are widely used in travel behavior analysis, especially in travel time and distance analysis. Unfortunately, any one kind of household traffic surveys has its own problems.
Ge Gao +5 more
doaj +1 more source
Operational Evidence of Changing Travel Patterns [PDF]
This paper utilizes a traffic counts database covering a ten year period (1976-1985) to identify travel trends for Montgomery County, a suburb of Washington D.C. Generally, travel behavior is analyzed using person based travel survey data.
Ajay Kumar, David Levinson
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source