Results 101 to 110 of about 41,892 (292)

A Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment

open access: yesAdvanced Science, EarlyView.
The mechanobiological basis of atherosclerotic progression and its contribution to spatial and temporal heterogeneity remain incompletely understood. Spatially resolved AFM measurements revealed that plaque formation and distinct regions (cap fibrosis, intimal fibrosis, and lipid‐rich core) exhibit heterogeneous elastic modulus and viscoelastic ...
Yidan Zhou   +13 more
wiley   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

open access: yesAdvanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang   +9 more
wiley   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu   +15 more
wiley   +1 more source

Cortex-wide spatiotemporal motifs of theta oscillations are coupled to freely moving behavior

open access: yesFrontiers in Systems Neuroscience
Multisensory information is combined across the cortex and assimilated into the continuous production of ongoing behavior. In the hippocampus, theta oscillations (4–12 Hz) radiate as large-scale traveling waves, and serve as a scaffold for neuronal ...
Nicholas J. Sattler, Michael Wehr
doaj   +1 more source

Habitat‐Specific Design Strategies for Untethered Soft Robots

open access: yesAdvanced Science, EarlyView.
Habitat shapes the design of untethered soft robots. Across land, water, air, and living tissues, environmental constraints govern viable combinations of compliant structures, actuation mechanisms, and energy delivery. This review connects these constraints with robotic performance and identifies design principles for advancing adaptable, durable, and ...
Siyang Li   +3 more
wiley   +1 more source

A review of ring-type rotational MEMS traveling-wave ultrasonic micromotors: design, detection, control, and application validation [PDF]

open access: gold
Jinxuan Xie   +9 more
openalex   +1 more source

Mechanism of Direct Acoustic Construction and Gradient Properties Tuning

open access: yesAdvanced Science, EarlyView.
Directed acoustic construction enables omnidirectional gradient tuning of fingerprint‐inspired microstructures. By investigating the DAC mechanisms, diamond particles are found to enhance acoustic physical, mechanical, and chemical effects, promoting acoustic curing and broadening the range of gradient property tuning.
Dandan Wu   +6 more
wiley   +1 more source

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