Results 101 to 110 of about 1,163,658 (291)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Blood pressure response to renal denervation is correlated with baseline blood pressure variability: a patient-level meta-analysis [PDF]

, 2018
Background: Sympathetic tone is one of the main determinants of blood pressure (BP) variability and treatment-resistant hypertension. The aim of our study was to assess changes in BP variability after renal denervation (RDN).
Berra, Elena, Blankestijn, Peter J., Bots, Michiel L., Burnier, Michel, Czarnecka, Danuta, de Jong, Mark R., Elvan, Arif, Fadl Elmula, Fadl Elmula M., Gordin, Daniel, Jacobs, Lotte, Kahan, Thomas, Kjeldsen, Sverre E., Mark, Patrick B., Miroslawska, Atena, Olszanecka, Agnieszka, Persu, Alexandre, Renkin, Jean, Rosa, Ján, Spaak, Jonas, Spiering, Wilko, Staessen, Jan A., Steigen, Terje K., Taylor, Alison H.M., the European Network COordinating research on Renal Denervation (ENCOReD), Thijs, Lutgarde, Tikkanen, Ilkka, Widimský, Jiří, Wuerzner, Gregoire   +27 more
core   +2 more sources

Export of miRNAs from activated macrophages is cooperative and HuR‐dependent

FEBS Letters, EarlyView.
This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

One Year Results of Faricimab for Aflibercept-Resistant Diabetic Macular Edema

Clinical Ophthalmology, 2023
Ryan B Rush1– 3 1Panhandle Eye Group, Amarillo, TX, USA; 2Southwest Retina Specialists, Amarillo, TX, USA; 3Department of Surgery, Texas Tech University Health Science Center, Amarillo, TX, USACorrespondence: Ryan B Rush, Southwest Retina Specialists ...
Rush RB
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Treatment resistant psicosis

European Psychiatry, 2011
The aim is to charactherize the clinical data: psychopathologic state, pharmacological treatment and sociodemographical data; in a population of long-term institutionalized schizophrenic patients. Treatment resistant patients will be compared to non treatment resistant schizophrenics.The target population is a convenience sample of our ...
J.D. Martínez Manjarrés, R. Gallardo Ponce, C. Botillo Martin, E. González Pablos   +3 more
openaire   +1 more source

Establishment of a patient-derived orthotopic Xenograft (PDOX) model of HER-2-positive cervical cancer expressing the clinical metastatic pattern. [PDF]

, 2015
Squamous cell carcinoma of the cervix, highly prevalent in the developing world, is often metastatic and treatment resistant with no standard treatment protocol.
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Ichikawa, Yasushi, Maawy, Ali, Mii, Sumiyuki, Miwa, Shinji, Momiyama, Masashi, Murakami, Takashi, Murata, Takuya, Tanaka, Kuniya, Uehara, Fuminari, Yamamoto, Mako, Yano, Shuya, Zhang, Nan, Zhang, Yong   +17 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.

Clinical and Biomedical Research, 2021
For years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations.
Marina Dalla Barba Londero, Mathias Hasse-Sousa, Carolina Petry-Perin, Felipe Cesar de Almeida Claudino, Letícia Sanguinetti Czepielewski, Clarissa Severino Gama   +5 more
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source