Results 91 to 100 of about 8,613,368 (310)

In vivo assessment of GABAergic inhibition and glutamate facilitation in treatment-resistant schizophrenia: a TMS study integrating clinical, cognitive, and neurophysiological evaluations

Schizophrenia
Treatment-resistant schizophrenia (TRS) affects approximately one-third of individuals with schizophrenia, posing significant challenges for clinical management.
Annarita Barone, Gianmaria Senerchia, Giuseppe De Simone, Marco Manzo, Mariateresa Ciccarelli, Stefano Tozza, Valentina Virginia Iuzzolino, Myriam Spisto, Raffaele Dubbioso, Felice Iasevoli, Rosa Iodice, Andrea de Bartolomeis   +11 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Metacognitive Therapy in Treatment-Resistant Psychosis:A Multiple-Baseline Study [PDF]

, 2013
Background: More effective psychological treatments for psychosis are required. Case series data and pilot trials suggest metacognitive therapy (MCT) is a promising treatment for anxiety and depression.
Wardle, Melissa, Morrison, Anthony P, Morrison, Anthony P., Morrison, A.P., Wells, A; id_orcid, Hutton, P., Hutton, Paul, Wardle, M., Wells, Adrian   +8 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Barriers to using clozapine in treatment-resistant schizophrenia: systematic review [PDF]

, 2019
Aims and methodTo systematically review the literature on barriers to the use of clozapine and identify any interventions for optimizing clozapine use in treatment-resistant schizophrenia. Journal databases were searched from 1972 to March 2018.
Farooq
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia. [PDF]

, 2012
Recent studies have shown that Plasmodium falciparum malaria parasites in Pailin province, along the border between Thailand and Cambodia, have become resistant to artemisinin derivatives. To better define the epidemiology of P.
Yeang, Chhiang, Shunmay Yeung, Nguon, Sokomar, Chea, Nguon, Thomson Andrew, Chhiang Yeang (130756), Steven Bjorge (130709), Khim Nimol, Samphornarann Top (130727), Habib, Najibullah, Robert D Newman, Andrew Thomson (23309), Menard, Didier, Sovann Yok, Kim Saorin, Kim, Saorin, Sophal, Uth, Bjorge Steven, Benoit Witkowski, Didier Menard (2577220), Najibullah Habib, Michelle M Thompson, Steven Bjorge, Sarorn Sum, Didier Menard, Nimol Khim (130700), Andrew Thomson, Christophel Eva-Maria, Ros, Seyha, Mellor Steve, Top Samphornarann, Hoyer Stefan, Bjorge, Steven, Socheat Duong, Saorin Kim, Menard Didier, Kheng, Sim, Nguon Chea, Hoyer, Stefan, Top, Samphornarann, Sokomar Nguon, Najibullah Habib (130696), Thompson Michelle M., Robert D. Newman (130763), Sarorn Sum (130703), Sophal Uth, Witkowski Benoit, Witkowski, Benoit, Sovann Yok (130723), Socheat Duong (130761), Newman, Robert D, Nguon Sokomar, Uth Sophal, Michelle M. Thompson, Michelle M. Thompson (130739), Duong, Socheat, Kheng Sim, Seyha Ros (130731), Mellor, Steve, Yeung, Shunmay, Chhiang Yeang, Ariey Frédéric, Seyha Ros, Samphornarann Top, Saorin Kim (130692), Christophel, Eva-Maria, Khim, Nimol, Steve Mellor, Sim Kheng (130715), Uth Sophal (130734), Chea Nguon, Eva-Maria Christophel, Nguon Chea (130719), Yok Sovann, Frédéric Ariey (92228), Ros Seyha, Sum, Sarorn, Nimol Khim, Thomson, Andrew, Frédéric Ariey, Yeang Chhiang, Newman Robert D., Sum Sarorn, Thompson, Michelle M, Habib Najibullah, Ariey, Frédéric, Duong Socheat, Yeung Shunmay, Eva-Maria Christophel (130705), Sim Kheng, Sokomar Nguon (130689), Stefan Hoyer (130687), Stefan Hoyer, Yok, Sovann, Robert D. Newman, Steve Mellor (130744), Benoit Witkowski (130751), Shunmay Yeung (53391)   +97 more
core   +1 more source

Untargeted 1H NMR-based metabolomics unveils distinct circulating biochemical signatures between treatment-resistant and non-treatment-resistant schizophrenia patients: a pilot study

Translational Psychiatry
Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population. Despite the availability of antipsychotic therapies, about 30% of patients develop treatment-resistant schizophrenia (TRS), defined by a lack of response to ...
Carmen Marino, Siwei Zhang, Giuseppe De Simone, Manuela Grimaldi, Anna Di Maio, Felice Iasevoli, Francesco Errico, Anna Maria D’Ursi, Andrea de Bartolomeis, Alessandro Usiello   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria [PDF]

, 2007
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Sibley, CH, Happi Christian T, Mbacham, W, Mugittu, K, Sutherland Colin J, Zimmerman, Peter A., Joshi, HH, Barnwell, JW, Naidoo, I, Happi, Christian T., Sutherland, Colin J, Sibley Carol H, Price Ric N, Mbacham, Wilfred, Happi, Christian T, Rosenthal Philip J, Barnwell, John W., Meshnick, Steven R, Shafer, RW, Plowe, CV, Roper, Cally, Zimmerman, PA, Sibley, Carol Hopkins, Shafer, Robert W, Barnwell John W, Barnwell, John W, Meshnick Steven R, Shafer, Robert W., Naidoo Inbarani, Sibley, Carol H, Joshi, Hema H., Sutherland, CJ, Meshnick, SR, Shafer Robert W, Rosenthal, Phillip J., Happi, CT, Rosenthal, PJ, Plowe Christopher V, Joshi, Hema H, Plowe, Christopher V., Rosenthal, Philip J, Mugittu Kefas, Roper Cally, Meshnick, Steven R., Zimmerman, Peter A, Sutherland, Colin J., Price, Ric N., Plowe, Christopher V, Mugittu, Kefas, Mbacham Wilfred, Naidoo, Inbarani, Price, RN, Price, Ric N, Zimmerman Peter A, Roper, C, Joshi Hema H, Happi, Christian, Zimmerman, Peter   +57 more
core   +1 more source