Results 81 to 90 of about 8,613,368 (310)

Interpersonal psychotherapy and mirtazapine versus mirtazapine alone in treatment resistant depressed patients with sequential functional brain scans of dopamine D2 receptors with IBZM spect [PDF]

, 2007
Twenty DSM-IV major depressed patients who had not responded to at least one previous trial of antidepressant therapy at an adequate dose and duration agreed to participate in this study. They were randomly assigned to receive either mirtazapine (30-45mg)
Robinson, Elizabeth
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Extensively drug resistant tuberculosis in South Africa [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 161-168).There are few data for treatment-related outcomes in patients with XDR tuberculosis in settings with high HIV prevalence.
Shean, Karen Penelope
core   +1 more source

Cognition in Treatment Resistant versus Non- Treatment Resistant Schizophrenia

European Psychiatry
IntroductionDespite antipsychotic treatment, around one-third of individuals of schizophrenia remain unresponsive.ObjectivesComparing cognitive impairments in TRS versus non-TRS patients.Methods50 adult patients with schizophrenia(DSM-5) were recruited in this cross-sectional cohort study, categorised into TRS (14) (treatment-resistant schizophrenia ...
Shah, Sanskruti, Patel, Kunj, Bhandari, Aditi, Porwal, Anshu, Lalwani, Nandini   +4 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application of 18F-FDG-PET with antipsychotic dose correction

Schizophrenia
Few studies using Positron Emission Tomography with 18F-fluorodeoxyglucose (18F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in schizophrenia, primarily focusing on metabolic activity, with none investigating connectivity ...
Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Valeria Gaudieri, Alberto Cuocolo, Mariateresa Ciccarelli, Sabina Pappatà, Andrea de Bartolomeis   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Systematic review of clinical effectiveness of interventions for treatment resistant late-life depression.

Treatment-resistant late-life depression (TRLLD) affects nearly half of older adults with major depression. This systematic review evaluates published evidence of effectiveness of both pharmacological and non-pharmacological treatments for TRLLD.
Gomez Bautista, D., Vandel, P., von Gunten, A., Stewart, R., Young, A.H., Orgeta, V., Mueller, C., Howard, R., Ranjbar, S., Pozuelo Moyano, B., Porras Ibarra, K.J., Reeves, S.   +11 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Molecular monitoring of resistant dhfr and dhps allelic haplotypes in Morogoro and Mvomero districts in south eastern Tanzania. [PDF]

, 2011
BACKGROUND\ud \ud Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa.
Abdullah, S, Kachur, P, Roper, C., Bloland, P., Pearce, R., Pearce, R, Mshinda, H, Mshinda, H., Malisa, A, Mutayoba, B, Roper, C, Abdullah, S., Kachur, P., Malisa, A., Mutayoba, B., Bloland, P   +15 more
core   +1 more source