Results 71 to 80 of about 6,753,495 (314)

Multidimensional Connectomics and Treatment-Resistant Schizophrenia: Linking Phenotypic Circuits to Targeted Therapeutics

Frontiers in Psychiatry, 2018
Schizophrenia is a very complex syndrome that involves widespread brain multi-dysconnectivity. Neural circuits within specific brain regions and their links to corresponding regions are abnormal in the illness.
Mary-Anne B. MacKay, John W. Paylor, James T. F. Wong, Ian R. Winship, Glen B. Baker, Serdar M. Dursun   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Molecular monitoring of resistant dhfr and dhps allelic haplotypes in Morogoro and Mvomero districts in south eastern Tanzania. [PDF]

, 2011
BACKGROUND\ud \ud Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa.
Abdullah, S, Kachur, P, Roper, C., Bloland, P., Pearce, R., Pearce, R, Mshinda, H, Mshinda, H., Malisa, A, Mutayoba, B, Roper, C, Abdullah, S., Kachur, P., Malisa, A., Mutayoba, B., Bloland, P   +15 more
core   +1 more source

Identifying treatment-resistant schizophrenia [PDF]

British Journal of Psychiatry, 2013
I was surprised to read the paper of Howes et al .[1][1] No control group was investigated. This paper implies that any patient for whom a third antipsychotic is considered ought to be considered for clozapine, and if they are not started on clozapine, this constitutes an unacceptable delay.
Kiriakos, Xenitidis, Colin, Campbell, Ann, Mortimer   +2 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia. [PDF]

, 2012
Recent studies have shown that Plasmodium falciparum malaria parasites in Pailin province, along the border between Thailand and Cambodia, have become resistant to artemisinin derivatives. To better define the epidemiology of P.
Yeang, Chhiang, Shunmay Yeung, Nguon, Sokomar, Chea, Nguon, Thomson Andrew, Chhiang Yeang (130756), Steven Bjorge (130709), Khim Nimol, Samphornarann Top (130727), Habib, Najibullah, Robert D Newman, Andrew Thomson (23309), Menard, Didier, Sovann Yok, Kim Saorin, Kim, Saorin, Sophal, Uth, Bjorge Steven, Benoit Witkowski, Didier Menard (2577220), Najibullah Habib, Michelle M Thompson, Steven Bjorge, Sarorn Sum, Didier Menard, Nimol Khim (130700), Andrew Thomson, Christophel Eva-Maria, Ros, Seyha, Mellor Steve, Top Samphornarann, Hoyer Stefan, Bjorge, Steven, Socheat Duong, Saorin Kim, Menard Didier, Kheng, Sim, Nguon Chea, Hoyer, Stefan, Top, Samphornarann, Sokomar Nguon, Najibullah Habib (130696), Thompson Michelle M., Robert D. Newman (130763), Sarorn Sum (130703), Sophal Uth, Witkowski Benoit, Witkowski, Benoit, Sovann Yok (130723), Socheat Duong (130761), Newman, Robert D, Nguon Sokomar, Uth Sophal, Michelle M. Thompson, Michelle M. Thompson (130739), Duong, Socheat, Kheng Sim, Seyha Ros (130731), Mellor, Steve, Yeung, Shunmay, Chhiang Yeang, Ariey Frédéric, Seyha Ros, Samphornarann Top, Saorin Kim (130692), Christophel, Eva-Maria, Khim, Nimol, Steve Mellor, Sim Kheng (130715), Uth Sophal (130734), Chea Nguon, Eva-Maria Christophel, Nguon Chea (130719), Yok Sovann, Frédéric Ariey (92228), Ros Seyha, Sum, Sarorn, Nimol Khim, Thomson, Andrew, Frédéric Ariey, Yeang Chhiang, Newman Robert D., Sum Sarorn, Thompson, Michelle M, Habib Najibullah, Ariey, Frédéric, Duong Socheat, Yeung Shunmay, Eva-Maria Christophel (130705), Sim Kheng, Sokomar Nguon (130689), Stefan Hoyer (130687), Stefan Hoyer, Yok, Sovann, Robert D. Newman, Steve Mellor (130744), Benoit Witkowski (130751), Shunmay Yeung (53391)   +97 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Barriers to using clozapine in treatment-resistant schizophrenia: systematic review [PDF]

, 2019
Aims and methodTo systematically review the literature on barriers to the use of clozapine and identify any interventions for optimizing clozapine use in treatment-resistant schizophrenia. Journal databases were searched from 1972 to March 2018.
Farooq
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source