Results 61 to 70 of about 6,753,495 (314)

The effectiveness of cognitive behavioral therapy on treatment-resistant depression

Chronic Diseases Journal, 2020
BACKGROUND: Treatment-resistant depression (TRD) is a severe and chronic form of major depression. It poses significant clinical, personal, and economic burden and does not respond to antidepressants. Psychotherapy can be a suggested option.
Rezvan Sadrmohammadi, Simin Gholamrezaei
doaj   +1 more source

Acceptance and Commitment Therapy group for treatment-resistant participants: a randomized controlled trial

, 2014
Acceptance and Commitment Therapy (ACT) is a theoretically coherent approach addressing common processes across a range of disorders. The aim of this study was to investigate the effectiveness of a group-based ACT intervention for ‘treatment-resistant ...
Clarke, Sue, James, Kirsty, Remington, Bob, Remington, B., James, K., Kingston, Jessica, Kingston, J., Bolderston, Helen   +7 more
core   +1 more source

Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy [PDF]

, 2009
Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer.
Pavlakis, Nick, Ross Davey, Davey, Ross, Nick Pavlakis, Britta Stordal, Stordal, Britta   +5 more
core   +1 more source

Treatment Resistant Hypertension

Ethnicity & Disease, 2015
<p>Treatment resistant hypertension (TRH) is defined by office blood pressure (BP) uncontrolled on ≥3 or controlled on ≥4 antihypertensive medications, preferably at optimal doses and including a diuretic. Apparent (a)TRH is used when optimal therapy, adherence, and measurement artifacts are unknown.
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children.

, 2012
BACKGROUND: Treatment options for drug-resistant tuberculosis (DR-TB) are limited. Linezolid has been successfully used to treat DR-TB in adults, but there are few case reports of its use in children for TB.
Rose, PC, Hallbauer, UM, Hesseling, AC, Schaaf, HS, Seddon, JA   +4 more
core   +1 more source

Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. [PDF]

, 2006
OBJECTIVES: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence
Targett Geoffrey A. T, Sutherland Colin J, Samuel Dunyo, Jawara, Musa, Coleman, Rosalind, Alexander Neal, Mesa, Eduardo, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, Ord Rosalynn, Coleman Rosalind, Musa Jawara, Geoffrey A. T Targett, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Sowe, Maimuna, Targett, Geoffrey AT, Eduardo Mesa, Dunyo, Samuel, Neal Alexander, Colin J Sutherland, Rosalind Coleman, Gijs Walraven, Sowe Maimuna, Walraven Gijs, Mesa Eduardo, Alexander, Neal, Margaret Pinder, Dunyo Samuel, Rosalynn Ord, Maimuna Sowe, Pinder, Margaret, Hallett Rachel   +35 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source