Results 41 to 50 of about 8,613,368 (310)

Treatment Resistant or Untreatable?

International Pharmacopsychiatry, 1978
Abstract Variety and magnitude of therapy-resistant depressive disorders continue to be of urgent interest to clinicians and researchers. In 1973, the section on pharmacopsychiatry of the World Psychiatric Association (WPA) held a symposium on Therapy-Resistant Depression, in Basel, Switzerland.
openaire   +2 more sources

Multidrug-resistant tuberculosis. [PDF]

, 2008
BACKGROUND: With almost 9 million new cases each year, tuberculosis remains one of the most feared diseases on the planet. Led by the STOP-TB Partnership and WHO, recent efforts to combat the disease have made considerable progress in a number of ...
Zager, Ellen M, McNerney, Ruth, McNerney Ruth, Zager Ellen M   +3 more
core   +1 more source

Investigating the effectiveness of oral ketamine on pain, mood and quality of life in treatment resistant chronic pain

Frontiers in Pain Research, 2023
IntroductionChronic pain is defined as pain lasting longer than 3 months. This often causes persistent emotional distress and functional disability that is refractory to conventional treatments.
Sammy Al Mukhaizeem, Sammy Al Mukhaizeem, Anurag Nasa, Anurag Nasa, Dympna Waldron, Dympna Waldron, Alex McDaid, Alex McDaid, Patrick J. Gorman, Patrick J. Gorman, Molly Featherstone, Molly Featherstone, Megan Barry, Megan Barry, Paul Murphy, Paul Murphy, Paul Murphy, Hugh Gallagher, Shrijit Nair, Michael O’Connor, Linda Kelly, Emma O'Hora, Roisin Dolan, Siaghal Mac Colgain, Jack McGrath, Stephane Blouin, Elena Roman, Elena Roman, Laura Gaffney, Darren William Roddy, Darren William Roddy, Kirk John Levins, Kirk John Levins, Kirk John Levins   +33 more
doaj   +1 more source

The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. [PDF]

, 2003
Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance.
East African Network for Monitoring Antimalarial Treatment (EANMAT), East African Network for Monitoring Antimalarial Treatment (EANM   +1 more
core   +1 more source

Microstructural evolution of FeCoNiCrMn high-entropy alloy subjected to laser shock peening: Molecular dynamics simulation study

Next Materials
Molecular dynamics (MD) and Monte Carlo (MC) simulations are used to study the microstructural evolution of FeCoNiCrMn high-entropy alloys (HEA) after laser shock peening (LSP).
Weizhou Xu, Yongxiang Geng, Haizhong Zheng, Yixin Xiao   +3 more
doaj   +1 more source

Xpert MTB/RIF and GenoType MTBDRplus assays for the rapid diagnosis of bone and joint tuberculosis

International Journal of Infectious Diseases, 2015
Background: Bone and joint tuberculosis (BJTB) constitutes about 10–20% of the extrapulmonary tuberculosis (EPTB) cases in China. The GenoType MTBDRplus assay (MTBDR) has been endorsed by the World Health Organization (WHO) for the diagnosis of pulmonary
Yunting Gu, Guirong Wang, Weijie Dong, Yunxu Li, Yifeng Ma, Yuanyuan Shang, Shibing Qin, Hairong Huang   +7 more
doaj   +1 more source

Treatment-resistant schizophrenia: How far have we traveled?

Frontiers in Psychiatry, 2022
Treatment-resistant schizophrenia is a lack of adequate response to antipsychotic medications resulting in incomplete functional and social recovery from the illness.
Ambu Pandey, Kamal Narayan Kalita
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]

, 2013
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack, Crampin, Amelia C., Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, Ram K Shrestha, Travers, Simon A, Simon A Travers, French, Neil, Glynn, Judith R, Crampin, Amelia C, Vijay Bansode, Judith R Glynn, Vijay Bansode, Amelia C Crampin, McCormack, Grace P, Travers, Simon A., Shrestha, Ram K., Ngwira, Bagrey, Shrestha, Ram K, Bagrey Ngwira, Bansode Vijay, French Neil, Ngwira Bagrey, Crampin Amelia C, McCormack Grace P, Travers Simon A, Glynn Judith R, Shrestha Ram K   +29 more
core   +2 more sources

Glutamate Metabotropic Receptors-Linked Postsynaptic Density Proteins: An Emergent Hub for Antipsychotics’ Regulation of Synaptic Plasticity and Metaplasticity

Biomolecules
Glutamate metabotropic receptors (mGluRs) and their molecular partners at the postsynaptic density (PSD) represent a highly dynamic molecular hub that integrates multiple neurotransmitter signals and regulates synaptic plasticity and metaplasticity ...
Annarita Barone, Licia Vellucci, Anita Nasti, Benedetta Mazza, Federica Iannotta, Felice Iasevoli, Andrea de Bartolomeis   +6 more
doaj   +1 more source