Results 101 to 110 of about 8,613,368 (310)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

One Year Results of Faricimab for Aflibercept-Resistant Diabetic Macular Edema

Clinical Ophthalmology, 2023
Ryan B Rush1– 3 1Panhandle Eye Group, Amarillo, TX, USA; 2Southwest Retina Specialists, Amarillo, TX, USA; 3Department of Surgery, Texas Tech University Health Science Center, Amarillo, TX, USACorrespondence: Ryan B Rush, Southwest Retina Specialists ...
Rush RB
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Multidrug-resistant tuberculosis treatment outcomes in Karakalpakstan, Uzbekistan: treatment complexity and XDR-TB among treatment failures. [PDF]

, 2007
BACKGROUND: A pilot programme to treat multidrug-resistant TB (MDR-TB) was implemented in Karakalpakstan, Uzbekistan in 2003. This region has particularly high levels of MDR-TB, with 13% and 40% among new and previously treated cases, respectively ...
Cox, H, Allamuratova, S, Hamraev A Karimovich, Rüsch-Gerdes Sabine, Yared Kebede, Zinaida N Tigay, Kalon Stobdan, Allamuratova Sholpan, Mills Clair, Karimovich Hamraev A., Karimovich, H, Tigay Zinaida N., Stobdan Kalon, Clair Mills, Rüsch-Gerdes, S, Sholpan Allamuratova, Kebede Yared, Tigay, Z, Mills, C, Kalon, S, Kebede, Y, Sizaire, V, Cox Helen S., Vinciane Sizaire, Sizaire Vinciane, Sabine Rüsch-Gerdes, Helen S Cox   +26 more
core   +2 more sources

Treatment-resistant schizophrenia criteria.

, 2023
Treatment-resistant schizophrenia refers to cases in which the symptoms of schizophrenia persist despite adequate and sufficient treatment with antipsychotics.
Mishell Sarmiento (16992311), Danny Raúl Zuñiga Carrasco (16974490), Christopher Del Valle (15462428), Malena Noboa (15520961), Andrea Valencia (16992319), Josselyn Anjhela Bravo (16711632), Aldo Molina (15442256), Luis Riofrio (15462407)   +7 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Treatment-resistant bipolar depression

, 2022
Treatment-resistant bipolar ...
J Quevedo (13303362), M Sanches (13329777), AP Diaz (14453508), BS Fernandes (14446122), JC Soares (14453523)   +4 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Augmentation of sertraline with aripiprazole in a case of treatment-resistant skin picking disorder

Gülhane Tıp Dergisi
Skin picking disorder (SPD) is a chronic psychiatric condition characterized by recurrent self-excoriation behaviors that often lead to marked psychosocial and functional impairment.
Özcan Uzun
doaj   +1 more source

Treatment resistance in schizophrenia [PDF]

British Journal of Psychiatry, 1993
S, Mirza, V S, Babu, E, Vithayathil
openaire   +2 more sources