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Defining treatment‐resistant depression
Varying conceptualizations of treatment-resistant depression (TRD) have made translating research findings or systematic reviews into clinical practice guidelines challenging and inconsistent.We conducted a review for the Centers for Medicare & Medicaid Services and the Agency for Healthcare Research and Quality to clarify how experts and investigators
Bradley N. Gaynes +12 more
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Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression.
New England Journal of Medicine, 2023BACKGROUND In treatment-resistant depression, commonly defined as a lack of response to two or more consecutive treatments during the current depressive episode, the percentage of patients with remission is low and the percentage with relapse is high ...
A. Reif +15 more
semanticscholar +1 more source
Journal of Psychiatric Research, 2022
Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The acute efficacy of ketamine in TRD has been demonstrated in replicated randomised-controlled trials (RCTs), but the generalizability of RCT data to real-world practice
Yazen Alnefeesi +14 more
semanticscholar +1 more source
Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The acute efficacy of ketamine in TRD has been demonstrated in replicated randomised-controlled trials (RCTs), but the generalizability of RCT data to real-world practice
Yazen Alnefeesi +14 more
semanticscholar +1 more source
Targeting Treatment-Resistant Depression
Journal of Pharmacy Practice, 2011Only 50% of depressed patients achieve remission of symptoms after 2 trials of antidepressants. Therefore one half of patients are considered treatment resistant. Studies have shown that with each failed antidepressant, chances of remission continue to decline. Untreated depressive symptoms lead to impaired social and occupational function, decline of
Monica, Mathys, Brian G, Mitchell
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Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression.
American Journal of Psychiatry, 2020OBJECTIVE New antidepressant treatments are needed that are effective, rapid acting, safe, and tolerable. Intermittent theta-burst stimulation (iTBS) is a noninvasive brain stimulation treatment that has been approved by the U.S.
E. Cole +27 more
semanticscholar +1 more source
American Journal of Psychiatry, 2021
OBJECTIVE Adolescent depression is prevalent and is associated with significant morbidity and mortality. Although intravenous ketamine has shown efficacy in adult treatment-resistant depression, its efficacy in pediatric populations is unknown.
J. Dwyer +8 more
semanticscholar +1 more source
OBJECTIVE Adolescent depression is prevalent and is associated with significant morbidity and mortality. Although intravenous ketamine has shown efficacy in adult treatment-resistant depression, its efficacy in pediatric populations is unknown.
J. Dwyer +8 more
semanticscholar +1 more source
Treatment-Resistant Depression
Psychotherapy and Psychosomatics, 1998Our ability to treat depression has improved with the availability of receptor-specific and chemically diverse groups of antidepressants. Even now, most of the short-term studies indicate that about 20% of depressed patients remain resistant to treatment. Therefore, it is important to properly assess the treatment-resistant depressed (TRD) patients and
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i Medicina
BACKGROUND Psilocybin-assisted psychotherapy (PAP) has been associated with antidepressant effects. Trials to date have typically excluded participants with complex presentations.
J. Rosenblat +34 more
semanticscholar +1 more source
BACKGROUND Psilocybin-assisted psychotherapy (PAP) has been associated with antidepressant effects. Trials to date have typically excluded participants with complex presentations.
J. Rosenblat +34 more
semanticscholar +1 more source

