Results 111 to 120 of about 59,572 (271)
British Journal of Pharmacology, EarlyView.Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux +26 more
wiley +1 more source
Prescribing trends in treatment-resistant schizophrenia
Psychiatry and Clinical Psychopharmacology, 2017 Objectives: Schizophrenia is a common mental health condition associated with significant morbidity and excess early mortality. Treatment-resistant schizophrenia (TRS) occurs in about one in three patients diagnosed with schizophrenia.
Aynur Görmez +3 more
doaj +1 more source
Child &Family Social Work, EarlyView.ABSTRACT Mothers who experience homelessness represent one of the most vulnerable and marginalized groups, often facing separation from their children as a consequence of housing instability and intersecting challenges. While there is a substantial body of research on parenting in the context of homelessness, little is known about the experience of ...
Olayinka Ariba +5 more
wiley +1 more source
Moderating factors for the effectiveness of group art therapy for schizophrenia: secondary analysis of data from the MATISSE randomised controlled trial. [PDF]
, 2014 Although some studies suggest that art therapy may be useful in the treatment of negative symptoms of schizophrenia, a recent large trial of group art therapy found no clinical advantage over standard care, but the study population was heterogeneous and ...
Killaspy, H +22 more
core +1 more source
Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review [PDF]
, 2017 Background Schizophrenia is a highly heterogeneous disorder, and around a third of patients are treatment-resistant. The only evidence-based treatment for these patients is clozapine, an atypical antipsychotic with relatively weak ...
Alice Egerton +17 more
core +1 more source
Regional and local divergence in welfare provision in England and Wales, 1776–1815
The Economic History Review, EarlyView.Abstract This article uses the township‐level data on welfare expenditure and provision gathered by parish officers in England and Wales at three points between 1776 and 1815 to illuminate regional and local differences during the period. These data have been linked to geographic information system (GIS) mapping systems, facilitating the mapping of ...
John Broad
wiley +1 more source
Genetic Studies in Treatment-Resistant Schizophrenia
, 2010 Treatment of patients with schizophrenia who fail to respond to adequate amounts of antipsychotics is a major challenge. The proportion of schizophrenia that is treatment-resistant has been estimated at 20–40%.
Vincenzo De Luca +7 more
core +1 more source
The FEBS Journal, EarlyView.Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito +8 more
wiley +1 more source
Frontiers in Psychiatry, 2018 Background: Patients with treatment-resistant schizophrenia (TRS) and non-treatment-resistant schizophrenia (NTRS) respond to antipsychotic drugs differently. Previous studies demonstrated that patients with TRS or NTRS exhibited abnormal neural activity
Shuzhan Gao +14 more
doaj +1 more source
Structured relaxation in the treatment of akathisia: case series
, 2010 Purpose: Akathisia remains a common side effect especially from antipsychotic medication.If the condition is diagnosed the management options are limited.Subjects/methodology: We tested a structured relaxation program on nine patients with adiagnosis of ...
L'Allemand, Thomas +7 more
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