Results 131 to 140 of about 59,572 (271)
Defining and characterising treatment-resistant schizophrenia
European Psychiatry, 1995 SummaryThis paper argues for a broader definition of treatment refractoriness that would include patients with partial drug responses, a relatively recent onset, less dramatic symptoms and intolerance to conventional drugs. The drug trials that define their responsiveness should be carefully conducted over a prolonged period of time, but need not ...
openaire +2 more sources
20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy
Journal of Microscopy, EarlyView.Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford +3 more
wiley +1 more source
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer +4 more
wiley +1 more source
Association between treatment resistance and cognitive function in schizophrenia
Singapore Medical JournalIntroduction: Treatment-resistant schizophrenia (TRS) affects around 30% of individuals with schizophrenia. About half of the patients with TRS who are treated with clozapine do not show a meaningful clinical response, that is, clozapine resistance.
Jiaqian Sun +6 more
doaj +1 more source
Augmentation of olanzapine in treatment-resistant schizophrenia
Journal of Psychiatry and Neuroscience, 2005 Objective: Up to 40% of patients with schizophrenic psychoses have symptoms that are resistant to monotherapy with antipsychotic drugs. In consequence, combinations of drugs are often used, especially based on the antipsychotic agents clozapine and olanzapine because of their broad receptor-interaction profile.
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Reading and relating with Frieda Fromm‐Reichmann and Joanne Greenberg
Critical Quarterly, EarlyView.
Joshua Pugh
wiley +1 more source
What Do Content Moderators Do? Emotion Work and Control on a Digital Health Platform
Journal of Management Studies, EarlyView.Abstract Content moderation determines the type of data displayed on platforms. Although this type of work is conducted online without interpersonal interactions, it does not remain emotionless. This article presents findings from a longitudinal qualitative study of how content moderation is conducted on a UK‐based platform that publishes patients ...
Dimitra Petrakaki, Andreas Kornelakis
wiley +1 more source
, 2013 The neuroanatomical structures underlying Major Depressive Disorder (MDD) are not fully understood. Invasive treatment options now exist that target the brain structures associated with MDD.
Grant, Frazer Alexander Lockhart
core
Occlusal Dysesthesia: Identifying Knowledge Gaps to Advance Clinical Care
Journal of Oral Rehabilitation, EarlyView.This scoping review highlights major knowledge gaps in the understanding of occlusal dysesthesia, including limited evidence on sensory, psychological and neurobiological mechanisms. Current theories remain largely unverified, underscoring the need for integrated biopsychosocial research to improve diagnosis and patient care.
Sara A. Esmat, Helen He, Iacopo Cioffi
wiley +1 more source
, 2002 Background. Social skills training and cognitive remediation are psychological techniques with considerable face validity for the treatment of negative symptoms of schizophrenia and their consequences.
Morgan, C +9 more
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