Results 171 to 180 of about 75,341 (263)

Personalizing Clozapine in Treatment-Resistant Schizophrenia: The Role of MicroRNA Biomarkers-A Pilot Study. [PDF]

open access: yesCurr Issues Mol Biol
Sosin DN   +7 more
europepmc   +1 more source

Inverse Association Between Betel Quid Use and Diabetes in Rural Bangladesh

open access: yesAmerican Journal of Human Biology, Volume 38, Issue 2, February 2026.
ABSTRACT Objectives Betel quid is used as a mild stimulant in many parts of South and East Asia and the Pacific. In observational studies, its use has been associated with elevated risk for diabetes, but studies in animal models suggest some component(s) of betel quid could reduce risk.
Kristin K. Sznajder   +9 more
wiley   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

open access: yesBrain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu   +1 more
wiley   +1 more source

Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature

open access: yesBrain and Behavior, Volume 16, Issue 2, February 2026.
Executive dysfunction in Huntington's disease follows a selective, stage‐dependent pattern, with early deficits in psychomotor speed, cognitive flexibility, inhibition, and working‐memory updating. Progression is associated with broader impairments in planning and attention.
Simone Migliore   +4 more
wiley   +1 more source

Highly Sensitive Dopamine Electrochemical Sensor Using Pt Nanoparticles on CNTs/Polypyrrole Nanocomposites

open access: yesElectrochemical Science Advances, Volume 6, Issue 1, February 2026.
ABSTRACT Dopamine (DA) plays a vital role as a neurotransmitter in the central nervous system (CNS), and its accurate quantification is essential for diagnosing neurological disorders. However, selective and sensitive detection of DA in complex biological matrices remains a challenge due to interference from coexisting biomolecules.
N. I. Nayem   +7 more
wiley   +1 more source

A two‐sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy

open access: yesEpilepsia Open, Volume 11, Issue 1, Page 78-88, February 2026.
Abstract Objective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. Methods Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium.
Huaiyu Sun   +7 more
wiley   +1 more source

Optimizing the patient journey: Insights from early implementation of long‐acting cabotegravir and rilpivirine in four urban Ryan White‐funded clinics in the United States

open access: yesJournal of the International AIDS Society, Volume 29, Issue 2, February 2026.
Abstract Introduction Long‐acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) represents a breakthrough in HIV treatment. However, understanding how to optimize real‐world service delivery and user experiences among people with HIV (PWH) remains limited. Methods Between August 2022 and December 2024, we conducted semi‐structured interviews with
Xavier A. Erguera   +17 more
wiley   +1 more source

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

open access: yesMedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin   +12 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo   +11 more
wiley   +1 more source

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