Results 61 to 70 of about 26,546 (243)

Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia [PDF]

Schizophrenia Bulletin, 2017
Treatment-resistant schizophrenia (TRS) affects around one-third of individuals with schizophrenia. Although a number of sociodemographic and clinical predictors of TRS have been identified, data on the genetic risk of TRS are sparse. We aimed to investigate the association between a polygenic risk score for schizophrenia and treatment resistance in ...
Wimberley, Theresa, Gasse, Christiane, Meier, Sandra Melanie, Agerbo, Esben, MacCabe, James H, Horsdal, Henriette Thisted   +5 more
openaire   +5 more sources

Patient‐ and Clinician‐Related Factors Associated With the Reduction in Opioid Use Among Adults With Chronic Non‐Cancer Pain: A Systematic Review

Clinical Pharmacology &Therapeutics, EarlyView.
Despite known risks, opioids are widely used for chronic non‐cancer pain (CNCP). Clinical guidelines now recommend deprescribing, but factors predicting success are poorly understood. This systematic review aimed to identify clinician and patient factors associated with attaining successful opioid dose reduction or discontinuation in adults with CNCP ...
Alessandra C. Marcelo, Sarah N. Hilmer, David J. Hunter, Stephanie Mathieson, Riyaas Mohamed, Leo Li, Natalie Fung, Anthony Yue, Manuela L. Ferreira   +8 more
wiley   +1 more source

Efficacy and tolerability of clozapine versus quetiapine in treatment-resistant schizophrenia

Indian Journal of Psychological Medicine, 2017
Objectives: To compare the efficacy and tolerability of clozapine and quetiapine in patients with treatment-resistant schizophrenia (TRS). Patients and Methods: In this prospective, randomized, open label study of 14 weeks, 53 patients with schizophrenia
Mitesh Kumar, B S Chavan, Ajeet Sidana, Subhash Das   +3 more
doaj   +1 more source

Tracking Glucose Trends, Unveiling Clinical Patterns: Insights From Continuous Glucose Monitoring in Patients at the Extreme of BMI and Eating Disorders Psychopathology

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Disturbances of glucose homoeostasis are claimed to act as both a consequence and maintaining factor in eating disorders (EDs). This study explored glucose trends and their association with real‐time food intake and self‐report eating psychopathology in a sample of patients with anorexia nervosa (AN) and binge‐eating disorder (BED ...
Marianna Rania, Concetta Irace, Raffaella Sacco, Mariateresa Bevacqua, Elvira Anna Carbone, Antonio Cutruzzolà, Maria Chiara Pelle, Franco Arturi, Cristina Segura‐Garcia   +8 more
wiley   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules

Neurobiology of Disease, 2013
Schizophrenia is a severe and common psychiatric disease with a lifetime prevalence of 0.5% to 1% globally. Because of limitations of the experimental approach in humans, valid animal models are essential in the effort to identify novel therapeutics for ...
Akihiro Mouri, Taku Nagai, Daisuke Ibi, Kiyofumi Yamada   +3 more
doaj   +1 more source

Managers' Decisions About Informal Accommodation Requests by Employees With and Without Disabilities

Human Resource Management, EarlyView.
ABSTRACT Although formal accommodations are required by law across many jurisdictions, many employees seek informal adjustments to their work conditions. These individualized work arrangements are not rooted in legal compliance but are instead provided at managers' discretion.
Silvia Bonaccio, Catherine E. Connelly, Matthew J. W. McLarnon, Ian R. Gellatly   +3 more
wiley   +1 more source

A COMPARISON OF EFFICACY AND SAFETY OF CLOZAPINE AND SULPIRIDE IN TREATMENT-RESISTANT SCHIZOPHRENIA

Psychiatry and Clinical Psychopharmacology, 2021
Object: In this study, a comparison of efficacy and tolerability of clozapine and sulpiride on treatment-resistant-schizophrenia was aimed. Method: Thirty-six in-patients with treatment-resistant schizophrenia, diagnosed according to DSM-IV diagnostic
Hasan Herken, Nazmiye Kaya, Lütfullah Beşiroğlu, Hüdaverdi Derman, İshak Özkan   +4 more
doaj  

FIGO best practice recommendations for the mental health of women at menopausal age

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Mental health during the menopausal transition requires focused attention to ensure supportive experiences for women. This review presents the International Federation of Gynecology and Obstetrics (FIGO) recommendations and summarizes the evidence, addressing 13 key questions framed by members of the FIGO Committee on Women at Menopausal Age ...
Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea Genazzani, Diana Ramos, Elizabete Argale, Gandhali Deshpande, Martha Hicky, Agnaldo Lopes Da Silva Filho, Enrique Herrera, Milan Balkrishnan   +10 more
wiley   +1 more source

Combined use of antipsychotics and electroconvulsive therapy in theurapetically resistant schizophrenia

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018
The article provides an overview of data in the literature devoted to the combined use of electroconvulsive therapy (ECT) and antipsychotics in treatment of resistant schizophrenia. ECT with anesthesia and muscle relaxants is a fairly safe method.
S. V. Sizov, Y. B. Barylnik
doaj