Results 161 to 170 of about 4,239,487 (340)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

CLINICAL EFFICACY OF LOOP DIURETIC TORASEMIDE IN TREATMENT OF PATIENTS WITH CHRONIC HEART FAILURE. RESULTS OF KAZAKHSTAN MULTICENTER STUDY "POET"

, 2014
Salim Berkinbaev, Г А Джунусбекова, А. Х. Исабекова   +2 more
openalex   +2 more sources

S114 Predictors of primary treatment failure in children with empyema [PDF]

, 2016
ES Ward-Booth, DA Spencer, JY Paton, SP Rushton, Malcolm Brodlie, MF Thomas   +5 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The Current Status of Chronic Renal Failure Patients on Regular Hemodialysis Treatment

, 1981
Kuniko Ito
openalex   +2 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Effective Treatment of a Case of Chronic Renal Failure Complicated by Nephrotic Syndrome with Hochu-Ekki-To and Keishi-Bukuryo-Gan-Ka-KokaDaio.

, 1996
Toshiaki Kogure, Hiroaki HIKIAMI, Yutaka Shimada, Takashi Itoh, Katsutoshi TERASAWA   +4 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

PCV102 PRESCRIPTION PATTERN & PHYSICIAN PROPENSITY FOR CONGESTIVE HEART FAILURE TREATMENTS IN UNITED STATES & EUROPE [PDF]

, 2019
Emelly Rusli, Riaz Ahmed, Aaron Galaznik, J. Ransom, A. Shilnikova, B. Lempernesse, Marjolein Y. Berger   +6 more
openalex   +1 more source

Two-year efficacy and safety of erenumab in participants with episodic migraine and 2–4 prior preventive treatment failures: results from the LIBERTY study [PDF]

, 2021
Michel Dominique Ferrari, Uwe Reuter, Peter J. Goadsby, Gabriel Paiva da Silva Lima, Subhayan Mondal, Shihua Wen, Nadia Tenenbaum, Shaloo Pandhi, Michel Lantéri‐Minet, Tracy Stites   +9 more
openalex   +1 more source