Results 91 to 100 of about 2,074,138 (265)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Machine learning-based identification of a consensus immune-derived gene signature to improve head and neck squamous cell carcinoma therapy and outcome

Frontiers in Pharmacology
BackgroundHead and neck squamous cell carcinoma (HNSCC), an extremely aggressive tumor, is often associated with poor outcomes. The standard anatomy-based tumor–node–metastasis staging system does not satisfy the requirements for screening treatment ...
Xueying Hu, Xueying Hu, Xueying Hu, Haiqun Dong, Haiqun Dong, Haiqun Dong, Wen Qin, Wen Qin, Wen Qin, Ying Bin, Ying Bin, Ying Bin, Wenhua Huang, Wenhua Huang, Wenhua Huang, Min Kang, Min Kang, Min Kang, Rensheng Wang, Rensheng Wang, Rensheng Wang   +20 more
doaj   +1 more source

Association of Physical Therapy Treatment Frequency in the Acute Care Hospital With Improving Functional Status and Discharging Home. [PDF]

Med Care, 2022
Johnson JK, Rothberg MB, Adams K, Lapin B, Keeney T, Stilphen M, Bethoux F, Freburger JK.   +7 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Identification and validation of potential diagnostic signature and immune cell infiltration for HIRI based on cuproptosis-related genes through bioinformatics analysis and machine learning

Frontiers in Immunology
Background and aimsCuproptosis has emerged as a significant contributor in the progression of various diseases. This study aimed to assess the potential impact of cuproptosis-related genes (CRGs) on the development of hepatic ischemia and reperfusion ...
Fang Xiao, Fang Xiao, Fang Xiao, Guozhen Huang, Guozhen Huang, Guozhen Huang, Guandou Yuan, Guandou Yuan, Guandou Yuan, Shuangjiang Li, Shuangjiang Li, Shuangjiang Li, Yong Wang, Yong Wang, Yong Wang, Zhi Tan, Zhi Tan, Zhi Tan, Zhipeng Liu, Zhipeng Liu, Zhipeng Liu, Stephen Tomlinson, Songqing He, Songqing He, Songqing He, Guoqing Ouyang, Guoqing Ouyang, Guoqing Ouyang, Yonglian Zeng, Yonglian Zeng, Yonglian Zeng   +30 more
doaj   +1 more source

Probabilistic Forecasting of Anti-VEGF Treatment Frequency in Neovascular Age-Related Macular Degeneration. [PDF]

Transl Vis Sci Technol, 2021
Pfau M, Sahu S, Rupnow RA, Romond K, Millet D, Holz FG, Schmitz-Valckenberg S, Fleckenstein M, Lim JI, de Sisternes L, Leng T, Rubin DL, Hallak JA.   +12 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities

Frontiers in Immunology
BackgroundAlcohol-associated steatohepatitis (ASH) is a globally prevalent liver disease, with robust evidence implicating neutrophil extracellular traps (NETs) as a central pathological phenomenon driving inflammation and progression.
Wei Gao, Wei Gao, Wei Gao, Zhiyong Lin, Zhiyong Lin, Zhiyong Lin, Yuntao Bao, Yuntao Bao, Yuntao Bao, Mingjiang Liu, Mingjiang Liu, Mingjiang Liu, Guangtao Ma, Guangtao Ma, Guangtao Ma, Xianxiang Chen, Xianxiang Chen, Xianxiang Chen, Shuiping Yu, Shuiping Yu, Shuiping Yu, Yonglian Zeng, Yonglian Zeng, Yonglian Zeng   +23 more
doaj   +1 more source

Early Data on Predictors of COVID-19 Treatment Frequency at Community Health Centers. [PDF]

J Prim Care Community Health, 2021
Goldstein EV, Seiber EE.
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source