Results 71 to 80 of about 2,074,138 (265)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Antimicrobial usage in broiler poultry farms in Zambia

Frontiers in Veterinary Science
Although Zambia and many other countries globally have very high rates of antimicrobial resistance, there is a surprisingly limited amount of quantitative data on antimicrobial use (AMU) to guide important control actions.
Isaac Silwamba, John Bwalya Muma, Geoffrey Mainda, NiwaelJesse MtuiMalamsha, Chitwambi Makungu, Kayula Mwila, Tabitha Kimani, Mark Caudell, Mark Obonyo, Charles Bebay, Suze Percy Filippini, Maria Hartmann, Sandra Brogden, Alina Kirse, Lothar Kreienbrock   +14 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Immunonutrients for radiation-induced oral mucositis in head and neck cancer: current evidence and future perspectives

Frontiers in Immunology
Radiation-induced oral mucositis (RIOM) is one of the most common and severe complications in patients with head and neck malignancies undergoing radiotherapy or chemoradiotherapy, with an incidence of 80–100%.
Xingqing Long, Xingqing Long, Xingqing Long, Chunye Fang, Chunye Fang, Chunye Fang, Xuezhen Qiu, Xuezhen Qiu, Xuezhen Qiu, Fayi Yu, Fayi Yu, Fayi Yu, Libing Chen, Libing Chen, Libing Chen, Xunmei Liu, Xunmei Liu, Xunmei Liu, Yuxin Li, Yuxin Li, Yuxin Li, Yinghua Chen, Yinghua Chen, Yinghua Chen, Rensheng Wang, Rensheng Wang, Rensheng Wang, Tingting Zhang, Tingting Zhang, Tingting Zhang   +29 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Radio Frequency Treatment for Postharvest Disinfestation of Dates

Chemical Engineering Transactions, 2015
Disinfestation is a necessary step in the packing chain of dates for fresh consumption and exposure to radio frequency radiation allows to carry out this operation minimizing the effect on the organoleptic characteristics of the fruits. The authors in a previous work evaluated the possibility of using this treatment for the disinfestation of dates ...
GARBATI PEGNA, FRANCESCO, SACCHETTI, PATRIZIA, CANUTI, VALENTINA, TRAPANI, SERENA, BERGESIO, CARLO, BELCARI, ANTONIO, ZANONI, BRUNO, Meggiolaro, Ferdinando .   +7 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source