Results 61 to 70 of about 2,074,138 (265)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Quantitative MRI in the assessment of clival invasion in locally advanced nasopharyngeal carcinoma

Frontiers in Oncology
ObjectiveThis study assesses the value of quantitative magnetic resonance imaging (qMRI) in evaluating clival invasion (CI) and monitoring therapeutic response in locally advanced nasopharyngeal carcinoma (LA-NPC).
Yuqing Lv, Yuqing Lv, Fayi Yu, Fayi Yu, Xunmei Liu, Xunmei Liu, Yifan Xu, Min Hu, Min Hu, Lulu Huang, Lulu Huang, Rensheng Wang, Rensheng Wang, Tingting Zhang, Tingting Zhang   +14 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A global analysis of nasopharynx cancer burden attributable to occupational formaldehyde exposure

Frontiers in Oncology
BackgroundOccupational formaldehyde is a significant risk factor for nasopharynx cancer. This study aimed to analyze the burden of nasopharynx cancer attributable to occupational formaldehyde using data from the Global Burden of Disease (GBD) 2021 ...
Jian Li, Jian Li, Yongjing Lai, Yongjing Lai, Anzhou Tang, Anzhou Tang, Xiang Yi, Xiang Yi   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Research advances in treatment strategies for breast cancer liver metastases: A comprehensive review

iLIVER
Breast cancer is the most prevalent malignancy in women globally, with metastatic disease accounting for approximately 90% of breast cancer-related deaths.
Liping Yan, Peng Tao
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Survey of drug use and its association with herd-level and farm-level characteristics on German dairy farms

Journal of Dairy Science
: The use of veterinary drugs is of similar importance to that of human drugs in addressing health challenges. In this context, pharmaceuticals and their metabolites inevitably enter soil and water in unknown quantities.
M. Abdallah, J. Bethäuser, F. Tettenborn, A. Hein, M. Hamann   +4 more
doaj   +1 more source