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Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression
New England Journal of Medicine, 2023BACKGROUND In treatment-resistant depression, commonly defined as a lack of response to two or more consecutive treatments during the current depressive episode, the percentage of patients with remission is low and the percentage with relapse is high ...
Oliveira-Maia Aj +2 more
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Treatment-Resistant Depression: Approaches to Treatment.
Journal of Psychosocial Nursing and Mental Health Services, 2021Approximately 30% of people treated for a major depressive episode will not achieve remission after two or more treatment trials of first-line antidepressants and are considered to have treatment-resistant depression (TRD). Because the odds of remission decrease with every subsequent medication trial, it is important for clinicians to ...
Karan S Kverno, Emma Mangano
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Esketamine for treatment resistant depression
Expert Review of Neurotherapeutics, 2019Introduction: Treatment Resistant Depression (TRD) is a common and burdensome condition with poor outcomes and few treatment options. Esketamine is the S-enantiomer of ketamine and has recently been FDA approved in the United States for treating depression that has failed to respond to trials of two or more antidepressants.
Serdar Dursun +2 more
exaly +5 more sources
American Journal of Psychiatry, 2023
One in three adults with major depressive disorder (MDD) do not experience clinically significant improvement after multiple sequential courses of antidepressants and have treatment-resistant depression (TRD).
M. Jha, S. Mathew
semanticscholar +1 more source
One in three adults with major depressive disorder (MDD) do not experience clinically significant improvement after multiple sequential courses of antidepressants and have treatment-resistant depression (TRD).
M. Jha, S. Mathew
semanticscholar +1 more source
Insomnia and treatment-resistant depression
2023Depression and sleep disturbance are related closely with bidirectional relationship. The heterogenic diagnostic criteria of major depressive disorder composed by the myriad combination of symptoms including sleep disturbance. Insomnia is an identifiable risk factor for depression and the treatment of insomnia might be able to prevent subsequent major ...
Wei-Chen, Lin, John Weyl, Winkelman
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Tinnitus and treatment-resistant depression
2023Tinnitus, a frequent disorder, is the conscious perception of a sound in the absence of a corresponding external acoustic sound source in the sense of a phantom sound. Although the majority of people who perceive a tinnitus sound can cope with it and are only minimaly impaired in their quality of lfe, 2-3% of the population perceive tinnitus as a major
Berthold, Langguth +6 more
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Journal of Psychiatric Research, 2022
Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The acute efficacy of ketamine in TRD has been demonstrated in replicated randomised-controlled trials (RCTs), but the generalizability of RCT data to real-world practice
Yazen Alnefeesi +14 more
semanticscholar +1 more source
Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The acute efficacy of ketamine in TRD has been demonstrated in replicated randomised-controlled trials (RCTs), but the generalizability of RCT data to real-world practice
Yazen Alnefeesi +14 more
semanticscholar +1 more source
Treatment‐resistant depression: resistant to definition?
Acta Psychiatrica Scandinavica, 2005Objective: To better define treatment‐resistant depression (TRD) so as to assist clinical management and refine treatment guidelines.Method: In this study, we examine a broad range of clinical variables in depressed patients (n = 196) referred to a tertiary referral Mood Disorders Unit (MDU).
G S, Malhi +4 more
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