Results 251 to 260 of about 260,799 (302)

Treatment-Resistant Depression: Approaches to Treatment

Journal of Psychosocial Nursing and Mental Health Services, 2021
Approximately 30% of people treated for a major depressive episode will not achieve remission after two or more treatment trials of first-line antidepressants and are considered to have treatment-resistant depression (TRD). Because the odds of remission decrease with every subsequent medication trial, it is important for clinicians to ...
Karan S, Kverno, Emma, Mangano
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Targeting Treatment-Resistant Depression

Journal of Pharmacy Practice, 2011
Only 50% of depressed patients achieve remission of symptoms after 2 trials of antidepressants. Therefore one half of patients are considered treatment resistant. Studies have shown that with each failed antidepressant, chances of remission continue to decline. Untreated depressive symptoms lead to impaired social and occupational function, decline of
Monica, Mathys, Brian G, Mitchell
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Defining treatment‐resistant depression

Depression and Anxiety, 2019
Varying conceptualizations of treatment-resistant depression (TRD) have made translating research findings or systematic reviews into clinical practice guidelines challenging and inconsistent.We conducted a review for the Centers for Medicare & Medicaid Services and the Agency for Healthcare Research and Quality to clarify how experts and investigators
Bradley N. Gaynes, Linda Lux, Gerald Gartlehner, Gary Asher, Valerie Forman‐Hoffman, Josh Green, Erin Boland, Rachel P. Weber, Charli Randolph, Carla Bann, Emmanuel Coker‐Schwimmer, Meera Viswanathan, Kathleen N. Lohr   +12 more
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Treatment‐resistant depression: resistant to definition?

Acta Psychiatrica Scandinavica, 2005
Objective:  To better define treatment‐resistant depression (TRD) so as to assist clinical management and refine treatment guidelines.Method:  In this study, we examine a broad range of clinical variables in depressed patients (n = 196) referred to a tertiary referral Mood Disorders Unit (MDU).
G S, Malhi, G B, Parker, J, Crawford, K, Wilhelm, P B, Mitchell   +4 more
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Treatment-Resistant Depression

Psychotherapy and Psychosomatics, 1998
Our ability to treat depression has improved with the availability of receptor-specific and chemically diverse groups of antidepressants. Even now, most of the short-term studies indicate that about 20% of depressed patients remain resistant to treatment. Therefore, it is important to properly assess the treatment-resistant depressed (TRD) patients and
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TREATMENT-RESISTANT BIPOLAR DEPRESSION

Psychiatric Clinics of North America, 1996
Patients with treatment-resistant bipolar depression require careful management, which takes into account the life-threatening potential of their depression and the risk of iatrogenic mania. Because there are few data specific to treatment of bipolar depression, much of the approach to bipolar depression is derived from experience with unipolar ...
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