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Overview of treatment-resistant depression.

Progress in Brain Research, 2023
Patients with major depressive disorder (MDD) often exhibit an inadequate treatment response or failure to achieve remission following treatment with antidepressant drugs. Treatment-resistant depression (TRD) is proposed to identify this clinical scenario.
Cheng-Ta Li
semanticscholar   +3 more sources

Management of Treatment-Resistant Depression

Psychiatric Clinics of North America, 2012
Given the limitations of evidence for treatment options that are consistently effective for TRD and the possibility that TRD is in fact a form of depression that has a low probability of resolving, how can clinicians help patients with TRD? Perhaps the most important conceptual shift that needs to take place before treatment can be helpful is to accept
Gabor I, Keitner, Abigail K, Mansfield
openaire   +2 more sources

Venlafaxine and treatment-resistant depression

Depression and Anxiety, 2000
Treatment-resistant depression (TRD) is an important clinical problem. This paper briefly reviews the definition of TRD and summarizes methodological issues that pertain to treatment research. Recent studies of venlafaxine treatment for TRD also are reviewed.
M E, Thase, E S, Friedman, R H, Howland
openaire   +2 more sources

Esketamine Monotherapy in Adults With Treatment-Resistant Depression

JAMA psychiatry
Key Points Question Is esketamine nasal spray used alone (without oral antidepressant) effective in treatment-resistant depression (TRD)? Findings In the efficacy analysis dataset of this double-blind, multicenter, randomized clinical trial of 378 adults
A. Janik   +10 more
semanticscholar   +1 more source

Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression.

American Journal of Psychiatry, 2020
OBJECTIVE New antidepressant treatments are needed that are effective, rapid acting, safe, and tolerable. Intermittent theta-burst stimulation (iTBS) is a noninvasive brain stimulation treatment that has been approved by the U.S.
E. Cole   +27 more
semanticscholar   +1 more source

Treatment-Resistant Depression

Psychotherapy and Psychosomatics, 1998
Our ability to treat depression has improved with the availability of receptor-specific and chemically diverse groups of antidepressants. Even now, most of the short-term studies indicate that about 20% of depressed patients remain resistant to treatment. Therefore, it is important to properly assess the treatment-resistant depressed (TRD) patients and
openaire   +2 more sources

Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial.

American Journal of Psychiatry, 2021
OBJECTIVE Adolescent depression is prevalent and is associated with significant morbidity and mortality. Although intravenous ketamine has shown efficacy in adult treatment-resistant depression, its efficacy in pediatric populations is unknown.
J. Dwyer   +8 more
semanticscholar   +1 more source

Psilocybin-assisted psychotherapy for treatment resistant depression: A randomized clinical trial evaluating repeated doses of psilocybin.

i Medicina
BACKGROUND Psilocybin-assisted psychotherapy (PAP) has been associated with antidepressant effects. Trials to date have typically excluded participants with complex presentations.
J. Rosenblat   +34 more
semanticscholar   +1 more source

Treatment-resistant depression and suicidality

Journal of Affective Disorders, 2018
Thirty percent of patients with treatment-resistant depression (TRD) attempt suicide at least once during their lifetime. However, it is unclear what the attempted and completed suicide incidences are in TRD patients after initiating a treatment, and whether specific treatments increase or decrease these incidences.We searched PubMed systematically for
Isidoor O. Bergfeld   +5 more
openaire   +2 more sources

Treatment-resistant depression.

The Journal of clinical psychiatry, 2006
info:eu-repo/semantics ...
Souery, Daniel   +2 more
openaire   +2 more sources

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