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Esketamine for treatment resistant depression
Expert Review of Neurotherapeutics, 2019Introduction: Treatment Resistant Depression (TRD) is a common and burdensome condition with poor outcomes and few treatment options. Esketamine is the S-enantiomer of ketamine and has recently been FDA approved in the United States for treating depression that has failed to respond to trials of two or more antidepressants.
Jennifer Swainson +2 more
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Treatment-Resistant Depression: Approaches to Treatment
Journal of Psychosocial Nursing and Mental Health Services, 2021Approximately 30% of people treated for a major depressive episode will not achieve remission after two or more treatment trials of first-line antidepressants and are considered to have treatment-resistant depression (TRD). Because the odds of remission decrease with every subsequent medication trial, it is important for clinicians to ...
Karan S, Kverno, Emma, Mangano
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Insomnia and treatment-resistant depression
2023Depression and sleep disturbance are related closely with bidirectional relationship. The heterogenic diagnostic criteria of major depressive disorder composed by the myriad combination of symptoms including sleep disturbance. Insomnia is an identifiable risk factor for depression and the treatment of insomnia might be able to prevent subsequent major ...
Wei-Chen, Lin, John Weyl, Winkelman
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Tinnitus and treatment-resistant depression
2023Tinnitus, a frequent disorder, is the conscious perception of a sound in the absence of a corresponding external acoustic sound source in the sense of a phantom sound. Although the majority of people who perceive a tinnitus sound can cope with it and are only minimaly impaired in their quality of lfe, 2-3% of the population perceive tinnitus as a major
Berthold, Langguth +6 more
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Treatment‐resistant depression: resistant to definition?
Acta Psychiatrica Scandinavica, 2005Objective: To better define treatment‐resistant depression (TRD) so as to assist clinical management and refine treatment guidelines.Method: In this study, we examine a broad range of clinical variables in depressed patients (n = 196) referred to a tertiary referral Mood Disorders Unit (MDU).
G S, Malhi +4 more
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Management of Treatment-Resistant Depression
Psychiatric Clinics of North America, 2012Given the limitations of evidence for treatment options that are consistently effective for TRD and the possibility that TRD is in fact a form of depression that has a low probability of resolving, how can clinicians help patients with TRD? Perhaps the most important conceptual shift that needs to take place before treatment can be helpful is to accept
Gabor I, Keitner, Abigail K, Mansfield
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Treatment-resistant depression and suicidality
Journal of Affective Disorders, 2018Thirty percent of patients with treatment-resistant depression (TRD) attempt suicide at least once during their lifetime. However, it is unclear what the attempted and completed suicide incidences are in TRD patients after initiating a treatment, and whether specific treatments increase or decrease these incidences.We searched PubMed systematically for
Isidoor O. Bergfeld +5 more
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Treatment-Resistant Depression
Psychotherapy and Psychosomatics, 1998Our ability to treat depression has improved with the availability of receptor-specific and chemically diverse groups of antidepressants. Even now, most of the short-term studies indicate that about 20% of depressed patients remain resistant to treatment. Therefore, it is important to properly assess the treatment-resistant depressed (TRD) patients and
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