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ECT in Treatment-Resistant Depression
American Journal of Psychiatry, 2012Electroconvulsive therapy (ECT), which has been in use for 75 years, is an important treatment for severe and treatment-resistant depression. Although it is acknowledged as the most effective acute treatment for severe mood and psychotic disorders, it remains controversial because of misperceptions about its use and lack of familiarity among health ...
Charles H, Kellner +5 more
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Venlafaxine and treatment-resistant depression
Depression and Anxiety, 2000Treatment-resistant depression (TRD) is an important clinical problem. This paper briefly reviews the definition of TRD and summarizes methodological issues that pertain to treatment research. Recent studies of venlafaxine treatment for TRD also are reviewed.
M E, Thase, E S, Friedman, R H, Howland
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Treatment-resistant depression.
The Journal of clinical psychiatry, 2006info:eu-repo/semantics ...
Souery, Daniel +2 more
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Treatment for Therapy-Resistant Depression
Psychopathology, 2010Thanks to progress in the diagnosis and treatment of depression it is now possible for most cases to be treated on an out-patient basis. Only 15–20% of patients require hospitalisation, most of them because their depression has proved resistant to therapy.
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Strategies for treatment-resistant depression
Clinical Cornerstone, 1999Clinical depression is a common disorder with serious implications that is often misdiagnosed or underestimated. More than 50% of suicides are associated with a major depressive disorder, and depression can adversely impact a variety of other medical conditions.
P G, Janicak, B, Martis
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Esketamine for Treatment-Resistant Depression
JAMA PsychiatryTo the Editor Janik et al reported a positive trial of esketamine monotherapy for treatment-resistant depression. However, the lead-in design and functional unblinding could have biased treatment estimates. The 4-week double-blind phase was preceded by a lead-in phase of up to 7 weeks, during which time antidepressant medication was discontinued ...
Cristea I. A., Plöderl M., Naudet F.
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Targeting Treatment-Resistant Depression
Journal of Pharmacy Practice, 2011Only 50% of depressed patients achieve remission of symptoms after 2 trials of antidepressants. Therefore one half of patients are considered treatment resistant. Studies have shown that with each failed antidepressant, chances of remission continue to decline.
Monica, Mathys, Brian G, Mitchell
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Treatment resistant depression in elderly
2023Treatment refractory depression (TRD) in the elderly is a common psychiatric disorder with high comorbidity and mortality. Older adults with TRD often have complicated comorbidities and several predisposing risk factors, which may lead to neuropsychiatric dysfunction and poor response to treatment.
Sheng-Chiang, Wang +4 more
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Defining treatment‐resistant depression
Depression and Anxiety, 2019Varying conceptualizations of treatment-resistant depression (TRD) have made translating research findings or systematic reviews into clinical practice guidelines challenging and inconsistent.We conducted a review for the Centers for Medicare & Medicaid Services and the Agency for Healthcare Research and Quality to clarify how experts and investigators
Bradley N. Gaynes +12 more
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Esketamine for treatment-resistant depression
Drug and Therapeutics Bulletin, 2020Generic name: Esketamine hydrochloride Brand name: Spravato Formulation: 28mg in 0.2ml nasal spray solution Market Authorisation holder: Janssen-Cilag International NV Indication: Treatment resistant
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