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Kaposi’s sarcoma-associated herpesvirus (KSHV) is the most common cause of Kaposi’s sarcoma (KS) and other malignant growths in humans. However, the lack of a KSHV-infected small animal model has hampered understanding of the mechanisms of KSHV infection,
Daoqun Li +9 more
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Tree shrew database (TreeshrewDB): a genomic knowledge base for the Chinese tree shrew [PDF]
The tree shrew (Tupaia belangeri) is a small mammal with a close relationship to primates and it has been proposed as an alternative experimental animal to primates in biomedical research. The recent release of a high-quality Chinese tree shrew genome enables more researchers to use this species as the model animal in their studies.
Yu Fan, Dandan Yu, Yong-Gang Yao
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A Novel Tree Shrew Model of Chronic Experimental Autoimmune Uveitis and Its Disruptive Application
BackgroundPrevious studies have established several animal models for experimental autoimmune uveitis (EAU) in rodents without the fovea centralis in the human retina.
Kaijiao Hu +19 more
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Genome of the Chinese tree shrew [PDF]
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as models for a variety of human disorders: depression, myopia, hepatitis B and C virus infections, and hepatocellular carcinoma, to name a few.
Fan, Yu +32 more
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A study of Epstein-Barr virus infection in the Chinese tree shrew(Tupaia belangeri chinensis)
Background Epstein–Barr virus (EBV) is closely associated with many human diseases, including a variety of deadly human malignant tumours. However, due to the lack of ideal animal models,the biological characteristics of EBV, particularly its function in
Zhi Wang +10 more
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The Tree Shrew as a Model for Cancer Research
Animal disease models are necessary in medical research, and an appropriate animal model is of great importance for studies about the prevention or treatment of cancer.
Tao Lu +6 more
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Coalescent-based genome analyses resolve the early branches of the euarchontoglires [PDF]
Despite numerous large-scale phylogenomic studies, certain parts of the mammalian tree are extraordinarily difficult to resolve. We used the coding regions from 19 completely sequenced genomes to study the relationships within the super-clade ...
A Criscuolo +52 more
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Tree shrews at the German Primate Center [PDF]
For many years, Tupaia (family Tupaiidae), most commonly known as tree shrews, have been studied almost exclusively by zoologists resulting in a controversial debate on their taxonomic status among mammals.
E. Fuchs
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Tree Shrew as a New Animal Model for the Study of Dengue Virus
Dengue virus is a significant public health threat worldwide; however, the pathogenesis of dengue disease remains poorly understood due to lack of appropriate small animal models.
Liming Jiang +6 more
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Tree shrews represent a suitable animal model to study the pathogenesis of human diseases as they are phylogenetically close to primates and have a well-developed central nervous system that possesses many homologies with primates.
Fang eShen +3 more
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