Results 171 to 180 of about 122,409 (259)

Regulatory B cells attenuate sepsis-associated pancreatic injury by regulating T cell homeostasis. [PDF]

Sci Rep
Liu P, Xiao Z, Lu X, Zhang X, Huang J.
europepmc   +1 more source

Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease? [PDF]

, 2008
Esaki M. Shankar, Ramachandran Vignesh, Vijayakumar Velu, Kailapuri G. Murugavel, Ramalingam Sekar, Pachamuthu Balakrishnan, Charmaine Lloyd, Shanmugam Saravanan, Suniti Solomon, Nagalingeswaran Kumarasamy   +9 more
openalex   +1 more source

Regulatory T cell‐derived interleukin‐15 promotes the diversity of immunological memory

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
We investigated the identity of IL‐15 producing cells using several mouse strains with cell type‐specific loss of IL‐15 expression. After the resolution of acute infection, IL‐15 secreted by regulatory cells, but not skeletal muscles or myeloid cells, was required for the maintenance of a subset of memory cells referred to as terminal effector memory T
Alaa Madi, Jingxia Wu, Sicong Ma, Nina Weisshaar, Alessa Mieg, Marvin Hering, Yanan Ming, Ferdinand Zettl, Kerstin Mohr, Nora ten Bosch, Tilo Schlimbach, Franziska Hertel, Guoliang Cui   +12 more
wiley   +1 more source

Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups

Angewandte Chemie, EarlyView.
A strategy for the conditional activation of therapeutic proteins utilizing removable peptide nucleic acid (PNA) masking groups is presented. Site‐specific installation of “Lock”‐PNAs containing a cleavage thioester linkage enabled steric blockage of receptor binding sites.
Bengt H. Gless, Elisabeth Jones, Carlos Labão‐Almeida, Cong Tang, Nicole Gottscheber, Renata Couto, Gonçalo J. L. Bernardes   +6 more
wiley   +2 more sources

Early Growth Response Gene 1 Benefits Autoimmune Disease by Promoting Regulatory T Cell Differentiation as a Regulator of Foxp3. [PDF]

Research (Wash D C)
Yang L, Han X, Wang M, Zhang X, Wang L, Xu N, Wu H, Shi H, Pan W, Huang F, Wu X.   +10 more
europepmc   +1 more source

TGFβ1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function [PDF]

, 2008
Ramireddy Bommireddy, George F. Babcock, Ram Raj Singh, Thomas Doetschman   +3 more
openalex   +1 more source

Antigen targeting to dendritic cells: Still a place in future immunotherapy?

European Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022
Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner, Nikolaus Romani, Christoph Rademacher, Hans Christian Probst, Karsten Mahnke   +4 more
wiley   +1 more source

CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells. [PDF]

Elife
Meng X, Zhu Y, Liu K, Wang Y, Liu X, Liu C, Zeng Y, Wang S, Gao X, Shen X, Chen J, Tao S, Xu Q, Dong L, Shen L, Wang L.   +15 more
europepmc   +1 more source

FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1 [PDF]

, 2008
Sang‐Myeong Lee, Beixue Gao, Deyu Fang
openalex   +1 more source

The thioredoxin system: Balancing redox responses in immune cells and tumors

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
The thioredoxin (TRX) system is a critical contributor to cellular redox homeostasis in all living cells. Here, we review the key roles of TRX for activation, proliferation, and responses in T cells, B cells, and myeloid cells. Further, we conceptualize how this knowledge may be therapeutically exploited for cancer treatment.
Jonathan Muri, Manfred Kopf
wiley   +1 more source