Results 341 to 350 of about 275,584 (397)

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Prostaglandin E₂-EP2/EP4 signaling induces the tumor-infiltrating Treg phenotype for tumor growth. [PDF]

Proc Natl Acad Sci U S A
Matsuura R, Punyawatthananukool S, Kawakami R, Mikami N, Sakaguchi S, Narumiya S.   +5 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Modified Guilu Erxian Glue regulates Treg immune function to suppress bone marrow failure in aplastic anemia mice. [PDF]

Chin Med
Liu W, Zhang P, Niu J, Zhang Y, Sun S, Sang J, Gao W, Meng B, Chai L.   +8 more
europepmc   +1 more source

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

TDRD3, a Tudor domain-containing protein, regulates <i>Klf2</i>-dependent T_reg differentiation and function to modulate immune tolerance. [PDF]

Sci Adv
Shi Y, Tao X, Shen L, Yuan YC, Wang G, Eurmsirilerd E, Chang R, Jia Z, Shang W, Yang Y, Sun Z.   +10 more
europepmc   +1 more source

Berberine Alleviates <i>Shigella</i>-Induced Dysentery by Regulating Intestinal Barrier and Inflammatory Responses. [PDF]

Int J Mol Sci
Ding J, Zhang Y, Fan X, Han Y, Lin Y.
europepmc   +1 more source

CD39⁺PD-1⁺ regulatory T cells in melanoma: key drivers of systemic immunosuppression and prognostic biomarkers. [PDF]

Front Oncol
Qiao G, He H, Wang X.
europepmc   +1 more source

Bone Marrow Mesenchymal Stromal Cell Osteogenesis is driven by Paracrine signals from Regulatory T Cell. [PDF]

Stem Cell Rev Rep
Baysal E, Al-Sharabi N, Mustafa K, Costea DE, Brennan M, Suliman S.   +5 more
europepmc   +1 more source

Effect of Lactobacillus salivarius on Th1/Th2 cytokines and the number of spleen CD4⁺ CD25⁺ Foxp3⁺ Treg in asthma Balb/c mouse.

, 2015
Yun Xiang, Yunxiao Shang, Miao Li
openalex   +1 more source