Results 361 to 370 of about 275,584 (397)
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Annals of the Rheumatic Diseases, 2010
Autoimmune diseases such as systemic lupus erythemathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and break-down of peripheral tolerance mechanisms.
M, Bonelli, J S, Smolen, C, Scheinecker
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Autoimmune diseases such as systemic lupus erythemathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and break-down of peripheral tolerance mechanisms.
M, Bonelli, J S, Smolen, C, Scheinecker
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Current Opinion in Organ Transplantation, 2012
Transfer of human regulatory T cells (Tregs) has become an attractive therapeutic alternative to improve the long-term outcome in transplantation and thus reduce the side-effects of conventional immunosuppressive drugs. Here, we summarize the recent findings on human Treg subsets, their phenotype and in-vivo function.In the last 2 years, it has become ...
Ulrike Schlieer +2 more
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Transfer of human regulatory T cells (Tregs) has become an attractive therapeutic alternative to improve the long-term outcome in transplantation and thus reduce the side-effects of conventional immunosuppressive drugs. Here, we summarize the recent findings on human Treg subsets, their phenotype and in-vivo function.In the last 2 years, it has become ...
Ulrike Schlieer +2 more
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Differentiation of Peripheral Treg
2022This chapter shows protocols for the differentiation of peripheral Treg (pTreg) from polyclonal and monoclonal CD4+ T cells. Polyclonal naïve CD4+ T cells can differentiate into pTreg upon adoptive transfer into Foxp3-diphtheria toxin receptor transgenic recipient mice in which endogenous Tregs are transiently depleted by administration of diphtheria ...
José, Almeida-Santos +2 more
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2021
Uveitis is a chronic disease with relapsing and remitting ocular attack, which requires corticosteroids and systemic immunosuppression to prevent severe vision loss. Classically, uveitis is referred to an autoimmune disease, mediated by pro-inflammatory Th17 cells and immunosuppressive CD4+CD25+FoxP3+ T-regulatory cells (Tregs).
Zhaohao, Huang, Wenli, Li, Wenru, Su
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Uveitis is a chronic disease with relapsing and remitting ocular attack, which requires corticosteroids and systemic immunosuppression to prevent severe vision loss. Classically, uveitis is referred to an autoimmune disease, mediated by pro-inflammatory Th17 cells and immunosuppressive CD4+CD25+FoxP3+ T-regulatory cells (Tregs).
Zhaohao, Huang, Wenli, Li, Wenru, Su
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Cyclophosphamide, DCs, and Tregs
Blood, 2010Certain chemotherapeutics are now known to augment host immunity by acting on DCs. In this issue of Blood , Nakahara and colleagues demonstrate a unique pharmacologic activity of CTX to selectively eliminate the lymphoid tissue-resident CD8+ DC subset in mice.[1][1] Although chemotherapeutic ...
Hironori, Matsushima, Akira, Takashima
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Th17 and Treg cells function in SARS‐CoV2 patients compared with healthy controls
Journal of Cellular Physiology, 2020In the course of the coronavirus disease 2019 (COVID‐19), raising and reducing the function of Th17 and Treg cells, respectively, elicit hyperinflammation and disease progression.
A. Sadeghi +12 more
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Platelets suppress Treg recruitment
Blood, 2010Apart from their canonical role in thrombosis and hemostasis, platelets amplify acute and chronic inflammation including atherosclerosis, and regulate the development and remodeling of blood and lymph vessels in health and disease. In this issue of Blood , Lievens and colleagues show evidence that activated platelets expressing CD40L promote ...
Rute, Moura, Marc, Tjwa
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2018
The heterogeneity and plasticity of T lymphocytes is critical for determining immune response outcomes. Functional regulatory T (Treg) cells are commonly characterized by stable FOXP3 expression and have reported to exhibit heterogeneous phenotypes under inflammatory conditions.
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The heterogeneity and plasticity of T lymphocytes is critical for determining immune response outcomes. Functional regulatory T (Treg) cells are commonly characterized by stable FOXP3 expression and have reported to exhibit heterogeneous phenotypes under inflammatory conditions.
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Blood, 2006
Comment on Prabhala et al, page [300][1] Multiple myeloma is associated with a deranged immune system, which is thought to be attributed to myeloma infiltration and interference of the bone marrow.
Qing Yi, Larry W. Kwak
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Comment on Prabhala et al, page [300][1] Multiple myeloma is associated with a deranged immune system, which is thought to be attributed to myeloma infiltration and interference of the bone marrow.
Qing Yi, Larry W. Kwak
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