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ATAC-ing human tissue Treg cells
Immunity, 2021What defines regulatory T (Treg) cells in healthy human tissues? In this issue of Immunity, Delacher et al. describe a human follicular helper T cell-like tissue-repair Treg cell signature governed by BATF based on chromatin accessibility data and link this on a transcriptome and protein level to important functional features like CCR8 expression.
Köhne, Maren Christin +1 more
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Nature Immunology, 2009
T cell antigen receptor (TCR)-transgenic models have been enormously influential in studies of T cell development in the thymus, particularly in terms of positive and negative selection. New transgenic mice produced with TCR genes cloned from regulatory T cells show that TCR specificity does 'instruct' regulatory T cell fate, within limits.
Kristin A, Hogquist, Amy E, Moran
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T cell antigen receptor (TCR)-transgenic models have been enormously influential in studies of T cell development in the thymus, particularly in terms of positive and negative selection. New transgenic mice produced with TCR genes cloned from regulatory T cells show that TCR specificity does 'instruct' regulatory T cell fate, within limits.
Kristin A, Hogquist, Amy E, Moran
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Treg cells in autoimmunity: from identification to Treg-based therapies
Seminars in Immunopathology, 2019Regulatory (Treg) cells are key regulators of inflammation and important for immune tolerance and homeostasis. A major progress has been made in the identification and classification of Treg cells. Due to technological advances, we have gained deep insights in the epigenetic regulation of Treg cells. The use of fate reporter mice allowed addressing the
Lisa, Göschl +2 more
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Single-Cell Transcriptome Analysis of Treg
2022Regulatory T-cells (Treg) are considerably heterogeneous. Thymically derived Treg (tTreg) are those, which differentiate in the thymus, while peripherally derived Treg (pTreg) differentiate from peripheral mature CD4+ T-cells. These two populations are often identified using markers such as neuropilin-1 and Helios (for tTreg) and ROR-γt (for pTreg) in ...
Benjy Jek Yang, Tan +2 more
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Stubborn Tregs limit T-cell therapy
Blood, 2012In this issue of Blood, Baba and colleagues characterize a residual pool ofCD4+CD25+Foxp3+ regulatory T cells (Tregs) surviving a nonmyeloablative conditioning regimen that undergo robust homeostatic expansion to limit the full potential of adoptive T-cell therapy (ACT) for the treatment of cancer.
Christopher A, Klebanoff +1 more
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Lipid signalling enforces functional specialization of Treg cells in tumours
Nature, 2021Jun Wei, Hao Shi, Wei Su
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CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours
Nature, 2021Roberta Zappasodi +2 more
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Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy
Nature Medicine, 2022Jay Y Spiegel +2 more
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