Results 241 to 250 of about 130,982 (298)

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

Advanced Science, EarlyView.
AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang   +15 more
wiley   +1 more source

Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics. [PDF]

Cell Death Dis
Mikulak J, Terzoli S, Marzano P, Cazzetta V, Martiniello G, Piazza R, Viano ME, Vitobello D, Portuesi R, Grizzi F, Hegazi MAAA, Fiamengo B, Basso G, Parachini L, Mannarino L, D'Incalci M, Marchini S, Mavilio D.   +17 more
europepmc   +1 more source

Anti‐Inflammatory Macrophage‐Derived Exosomes Modified With Self‐Antigen Peptides for Treatment of Experimental Autoimmune Encephalomyelitis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Anti‐inflammatory macrophage‐derived exosomes modified with selfantigen peptides are developed to induce antigen‐specific immune tolerance. These exosomes demonstrate prophylactic effects in experimental autoimmune encephalomyelitis. Abstract Current treatments for autoimmune diseases often involve broad‐acting immunosuppressants, which carry risks ...
Qiaoyun Li, Jinwon Park, Jung Suk Kim, Quoc‐Viet Le, Jaiwoo Lee, Yu‐Kyoung Oh   +5 more
wiley   +1 more source

Single-cell RNA sequencing reveals an IL1R2+Treg subset driving immunosuppressive microenvironment in HNSCC. [PDF]

Cancer Immunol Immunother
Guo H, Liu C, Wu K, Li Y, Zhang Z, Chen F.   +5 more
europepmc   +1 more source

Identification of Three Distinct Subgroups in Antiphospholipid Syndrome: Implication for Sex Differences and Prognostic Outcomes from a Multicenter Study

Advanced Science, Volume 12, Issue 15, April 17, 2025.
A large‐scale, multicenter, and two‐stage study is conducted to define antiphospholipid syndrome (APS) subgroups. By applying unsupervised K‐means clustering algorithm, the authors identified three distinct APS subgroups: obstetric APS, female thrombotic APS (tAPS), and male tAPS, which display marked differences in clinical manifestations and ...
Chen Chen, Ao Zhang, Jianhui Cheng, Zhongqiang Yao, Juan Meng, Yilu Qin, Qingyi Lu, Yufei Li, Xiangjun Liu, Tianhao Li, Chao Hou, Yundi Tang, Hongjiang Liu, Ning Xu, Sai Dong, Xinxin Li, Fangmin Xu, Jianping Guo, Chun Li   +18 more
wiley   +1 more source

AN IRRADIATION-FREE PROTOCOL FOR MIXED CHIMERISM AND TOLERANCE THROUGH TREG-THERAPY

, 2008
Nina Pilat, Ulrike Baranyi, Christoph Klaus, Elmar Jaeckel, Nonsikelelo Mpofu, Ferdinand Muehlbacher, Thomas Wekerle   +6 more
openalex   +1 more source

ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development. [PDF]

Redox Biol
Satooka H, Nakamura Y, Hirata T.
europepmc   +1 more source

M6A Modified miR‐31‐5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7

Advanced Science, Volume 12, Issue 17, May 8, 2025.
The upregulation of FTO in autoimmune dry eye suppresses the recognition of pri‐miR‐31 by DGCR8, thereby inhibiting the maturation of miR‐31‐5p and reducing its inhibitory effect on the target gene P2RX7. The activation of P2RX7 subsequently triggers the p38 MAPK signaling pathway and increases the level of M1‐related genes, thus exacerbating the ...
Lu Zhao, Xuejia Li, Min Gao, Lin Liu, Binyun Ma, Xun Liu, Jiachen Zhang, Ruoxuan Liu, Bei Du, Ruihua Wei, Hong Nian   +10 more
wiley   +1 more source

Prognostic Role of Adaptive Immune Microenvironment in Patients with High-Risk Myelodysplastic Syndromes Treated with 5-Azacytidine. [PDF]

Cancers (Basel)
Tsakiraki Z, Spathis A, Bouchla A, Pouliakis A, Vryttia P, Panayiotides IG, Pappa V, Papageorgiou SG, Foukas PG.   +8 more
europepmc   +1 more source

Reprogramming the Tumor Immune Microenvironment with ICAM‐1‐Targeted Antibody‒Drug Conjugates and B7‐H3‐CD3 Bispecific Antibodies

Advanced Science, Volume 12, Issue 16, April 24, 2025.
Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou, Mengyu Hong, Dan Zhao, Wenyu Li, Xiaolong Yuan, Yinghong Wang, Hualong Li, Yang Yang, Tengchuan Jin, Jing Pan   +9 more
wiley   +1 more source