Results 261 to 270 of about 120,068 (304)
Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs [PDF]
Immunological Reviews, 2014 The identification of CD25 and subsequently Forkhead box protein 3 (Foxp3) as markers for regulatory T cells (Tregs) has revolutionized our ability to explore this population experimentally.
Lucy Walker, Kesley Attridge
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Antigen Specificity Enhances Disease Control by Tregs in Vitiligo [PDF]
Frontiers in Immunology, 2020 Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral skin Tregs can provide protection against depigmentation. Ganglioside D3 (GD3) is
I Caroline le Poole +2 more
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Molecular Biology Reports, 2021
Atherosclerosis involves both innate and adaptive immunity. Here, we provide an overview of the role of regulatory T (Treg) cells in atherosclerotic diseases. Treg cells and their inhibitory cytokines, IL-10 and TGF-β, have been identified in atherosclerotic lesions and to inhibit progression through lipoprotein metabolism modulation.
Rebecca Kuan +2 more
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Atherosclerosis involves both innate and adaptive immunity. Here, we provide an overview of the role of regulatory T (Treg) cells in atherosclerotic diseases. Treg cells and their inhibitory cytokines, IL-10 and TGF-β, have been identified in atherosclerotic lesions and to inhibit progression through lipoprotein metabolism modulation.
Rebecca Kuan +2 more
openaire +2 more sources
Annals of the Rheumatic Diseases, 2010
Autoimmune diseases such as systemic lupus erythemathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and break-down of peripheral tolerance mechanisms.
M, Bonelli, J S, Smolen, C, Scheinecker
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Autoimmune diseases such as systemic lupus erythemathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and break-down of peripheral tolerance mechanisms.
M, Bonelli, J S, Smolen, C, Scheinecker
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Differentiation of Peripheral Treg
2022This chapter shows protocols for the differentiation of peripheral Treg (pTreg) from polyclonal and monoclonal CD4+ T cells. Polyclonal naïve CD4+ T cells can differentiate into pTreg upon adoptive transfer into Foxp3-diphtheria toxin receptor transgenic recipient mice in which endogenous Tregs are transiently depleted by administration of diphtheria ...
José, Almeida-Santos +2 more
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Cyclophosphamide, DCs, and Tregs
Blood, 2010Certain chemotherapeutics are now known to augment host immunity by acting on DCs. In this issue of Blood , Nakahara and colleagues demonstrate a unique pharmacologic activity of CTX to selectively eliminate the lymphoid tissue-resident CD8+ DC subset in mice.[1][1] Although chemotherapeutic ...
Hironori, Matsushima, Akira, Takashima
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2021
Uveitis is a chronic disease with relapsing and remitting ocular attack, which requires corticosteroids and systemic immunosuppression to prevent severe vision loss. Classically, uveitis is referred to an autoimmune disease, mediated by pro-inflammatory Th17 cells and immunosuppressive CD4+CD25+FoxP3+ T-regulatory cells (Tregs).
Zhaohao, Huang, Wenli, Li, Wenru, Su
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Uveitis is a chronic disease with relapsing and remitting ocular attack, which requires corticosteroids and systemic immunosuppression to prevent severe vision loss. Classically, uveitis is referred to an autoimmune disease, mediated by pro-inflammatory Th17 cells and immunosuppressive CD4+CD25+FoxP3+ T-regulatory cells (Tregs).
Zhaohao, Huang, Wenli, Li, Wenru, Su
openaire +2 more sources
Immunometabolism of Tregs: mechanisms, adaptability, and therapeutic implications in diseases [PDF]
Frontiers in ImmunologyImmunometabolism is an emerging field that explores the intricate interplay between immune cells and metabolism. Regulatory T cells (Tregs), which maintain immune homeostasis in immunometabolism, play crucial regulatory roles.
Dengfu Yao, Min Yao, Lin-Ling Ju
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Current Opinion in Organ Transplantation, 2012
Transfer of human regulatory T cells (Tregs) has become an attractive therapeutic alternative to improve the long-term outcome in transplantation and thus reduce the side-effects of conventional immunosuppressive drugs. Here, we summarize the recent findings on human Treg subsets, their phenotype and in-vivo function.In the last 2 years, it has become ...
Ulrike Schlieer +2 more
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Transfer of human regulatory T cells (Tregs) has become an attractive therapeutic alternative to improve the long-term outcome in transplantation and thus reduce the side-effects of conventional immunosuppressive drugs. Here, we summarize the recent findings on human Treg subsets, their phenotype and in-vivo function.In the last 2 years, it has become ...
Ulrike Schlieer +2 more
openaire +2 more sources
2018
The heterogeneity and plasticity of T lymphocytes is critical for determining immune response outcomes. Functional regulatory T (Treg) cells are commonly characterized by stable FOXP3 expression and have reported to exhibit heterogeneous phenotypes under inflammatory conditions.
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The heterogeneity and plasticity of T lymphocytes is critical for determining immune response outcomes. Functional regulatory T (Treg) cells are commonly characterized by stable FOXP3 expression and have reported to exhibit heterogeneous phenotypes under inflammatory conditions.
openaire +1 more source