Results 301 to 310 of about 203,023 (389)

Foxp3 and BATF cooperatively direct cis -regulatory programs and gene expression for functional differentiation of Treg cells [PDF]

Ryuichi Murakami, Norihito Hayatsu, Takahisa Miyao, Zhi Liu, S. Shibata, Masashi Matsuda, Yusuke Iizuka, Hideyuki Yoshida, Yoshinori Hasegawa, Wataru Ise, Haruhiko Koseki, Tomohiro Kurosaki, Shohei Hori   +12 more
openalex   +1 more source

MR‐DELTAnet: A Longitudinal MRI‐Transformer Model Predicting Pathological Complete Response and Revealing Immune Microenvironment via scRNA‐seq in Locally Advanced Rectal Cancer

Advanced Science, EarlyView.
The MR‐DELTAnet model utilizes longitudinal MRI to predict treatment response after neoadjuvant chemoradiotherapy in locally rectal cancer patients, accurately identifying patients likely to achieve pathological complete response for personalized management.
Wuteng Cao, Huaxian Chen, Jiao Li, Yihui Zheng, Liqing Xie, Guozhong Xiao, Zeyan Wang, Fen Yuan, Junhong Chen, Chongbao Sun, Jing Dai, Jinping Zeng, Xinhua Wang, Lei Wu, Hongcheng Lin   +14 more
wiley   +1 more source

ROSE12, a novel anti-CTLA-4 FcγRs binding-enhanced antibody activated by extracellular adenosine triphosphate, shows tumor-selective regulatory T-cell depletion and antitumor efficacy without systemic immune activation. [PDF]

J Immunother Cancer
Hayashi H, Tatsumi K, Katada H, Matsuda Y, Tsunenari T, Honda M, Nemoto T, Shimizu S, Miura-Okuda M, Ikuta Y, Ito A, Ogami C, Kato C, Kamimura M, Kibayashi T, Kubo C, Komatsu S, Komori Y, Shinozuka J, Susumu H, Tanno H, Tomii Y, Nakagawa K, Nagano H, Nanami M, Nishito Y, Fujisawa N, Matsushita T, Michisaka S, Yamazaki M, Yoshimoto M, Wakatsuki H, Wakabayashi T, Wada NA, Ueda O, Konishi H, Kashima K, Tanaka H, Endo M, Kitazawa T, Sakaguchi S, Kamata-Sakurai M, Igawa T.   +42 more
europepmc   +1 more source

Electroacupuncture regulates Th17/Treg cell balance through SIRT1 mediated anti-inflammatory pathway to improve insulin resistance induced obesity [PDF]

Wenyan Wang, Shurui Yang, Jing Liu, Shang Huang, Y. Li, Feng-Xia Liang   +5 more
openalex   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Automated GMP-compatible production of universal CAR Tregs for organ-targeted tolerance induction. [PDF]

J Transl Med
Lakshmi K, Jutrzenka-Trzebiatowski AV, Loureiro L, Soto KEG, Peter K, Morales JMM, Nirmala SS, Berndt N, Arndt C, Hu Y, Li JW, Peitzsch C, Taubenberger A, Wehner R, Schmitz M, Hölig K, Abken H, Bonifacio E, Bornhäuser M, Bachmann M, Feldmann A, Fuchs A.   +21 more
europepmc   +1 more source

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang   +14 more
wiley   +1 more source

Regulatory T-cells in Reproductive Medicine: Implications for Endometriosis-Associated Infertility and Implantation Immunity. [PDF]

Cureus
Taguchi S, Hayashi T.
europepmc   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source