Results 311 to 320 of about 203,023 (389)

Micro‐Organ Chip Deciphers Tumor‐Derived G‐CSF as Remote Commander of Lung Pre‐Metastatic Niche via VEGFA‐KDR Cascade

open access: yesAdvanced Science, EarlyView.
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Jingxin Zhang   +12 more
wiley   +1 more source

Prostaglandin E<sub>2</sub>-EP2/EP4 signaling induces the tumor-infiltrating Treg phenotype for tumor growth. [PDF]

open access: yesProc Natl Acad Sci U S A
Matsuura R   +5 more
europepmc   +1 more source

Transplant trials with Tregs: perils and promises.

open access: yesJournal of Clinical Investigation, 2017
Q. Tang, F. Vincenti
semanticscholar   +1 more source

TREG cell therapy [PDF]

open access: yesNature Reviews Rheumatology, 2010
openaire   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

open access: yesAdvanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang   +2 more
wiley   +1 more source

ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice

open access: yesCellular & Molecular Immunology, 2019
Tian Deng   +6 more
semanticscholar   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang   +7 more
wiley   +1 more source

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