Results 41 to 50 of about 99,148 (259)

Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators

Angewandte Chemie, EarlyView.
The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase   +9 more
wiley   +2 more sources

Versatile approach towards fully desymmetrized trehalose with a novel set of orthogonal protecting groups

Frontiers in Chemistry
Trehalose-containing glycans play an essential role in bacterial pathogenesis, host-pathogen interaction, and cell signaling. The investigation of trehalose uptake and metabolism in Mycobacteria using synthetic desymmetrized trehalose probes is an ...
Tomáš Vašíček, Benjamin Arensmeyer, Alessandro Monti, Alla Zamyatina   +3 more
doaj   +1 more source

Simple Syntheses of New Pegylated Trehalose Derivatives as a Chemical Tool for Potential Evaluation of Cryoprotectant Effects on Cell Membrane

Molecules, 2020
In our work, we developed the synthesis of new polyfunctional pegylated trehalose derivatives and evaluated their cryoprotective effect using flow cytometry.
Karel Pomeisl, Jan Richter, Martin Golan, Irena Kratochvílová   +3 more
doaj   +1 more source

A Snapshot of the Trehalose Pathway During Seed Imbibition in Medicago truncatula Reveals Temporal- and Stress-Dependent Shifts in Gene Expression Patterns Associated With Metabolite Changes

Frontiers in Plant Science, 2019
Trehalose, a non-reducing disaccharide with multiple functions, among which source of energy and carbon, stress protectant, and signaling molecule, has been mainly studied in relation to plant development and response to stress.
Anca Macovei, Andrea Pagano, Michela Cappuccio, Michela Cappuccio, Lucia Gallotti, Daniele Dondi, Susana De Sousa Araujo, Pedro Fevereiro, Pedro Fevereiro, Alma Balestrazzi   +9 more
doaj   +1 more source

Trehalose maintains vitality of mouse epididymal epithelial cells and mediates gene transfer. [PDF]

PLoS ONE, 2014
In the present study, trehalose was utilized to improve primary culture of mouse epididymal epithelial cells in vitro, and to enhance naked DNA delivery in epididymis in vivo.
Bin Qu, Yihua Gu, Jian Shen, Jinzhou Qin, Jianqiang Bao, Yuan Hu, Wenxian Zeng, Wuzi Dong   +7 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Trehalose Metabolism and Signaling

Annual Review of Plant Biology, 2008
Trehalose metabolism and signaling is an area of emerging significance. In less than a decade our views on the importance of trehalose metabolism and its role in plants have gone through something of a revolution. An obscure curiosity has become an indispensable regulatory system.
Paul, M. J., Primavesi, L. F., Jhurreea, D., Zhang, Y.   +3 more
openaire   +2 more sources

Trehalose metabolism in plants [PDF]

The Plant Journal, 2014
SummaryTrehalose is a quantitatively important compatible solute and stress protectant in many organisms, including green algae and primitive plants. These functions have largely been replaced by sucrose in vascular plants, and trehalose metabolism has taken on new roles.
John Edward Lunn, Ines Delorge, Carlos María Figueroa, Patrick Van Dijck, Mark Stitt   +4 more
openaire   +4 more sources

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

Advanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin, Wenbing Jiang, Kai Xin Thong, Zeynep Ulker, Brihitejas Patel, Cynthia Yu‐Wai‐Man   +5 more
wiley   +1 more source

Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosa.

PLoS Genetics, 2021
An important prelude to bacterial infection is the ability of a pathogen to survive independently of the host and to withstand environmental stress. The compatible solute trehalose has previously been connected with diverse abiotic stress tolerances ...
Stuart D Woodcock, Karl Syson, Richard H Little, Danny Ward, Despoina Sifouna, James K M Brown, Stephen Bornemann, Jacob G Malone   +7 more
doaj   +1 more source