Results 51 to 60 of about 55,407 (178)
Synthetic microbial communities for engineering climate‐smart biofertilizers
iMeta, EarlyView.Global agricultural productivity is increasingly destabilized by climate change—driven droughts, floods, extreme heat, and severe storms. Although the climate‐smart agriculture (CSA) framework addresses these challenges, implementation has focused mainly on plant genetics and agronomic inputs, leaving the adaptive potential of the crop microbiome ...
Yan Liu +9 more
wiley +1 more source
Microbial and metabolic impacts of trehalose and trehalose analogues
Gut Microbes, 2020 Trehalose is a disaccharide and fasting-mimetic that has been both canonized and vilified for its putative cardiometabolic and microbial effects. Trehalose analogues are currently under development to extend the key metabolic therapeutic actions of ...
Yiming Zhang, Brian J. DeBosch
doaj +1 more source
Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security
Journal of the Science of Food and Agriculture, EarlyView.Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori +9 more
wiley +1 more source
Current Issues in Molecular BiologyDonation after circulatory death (DCD) is a promising strategy for alleviating donor shortage in heart transplantation. Trehalose, an autophagy inducer, has been shown to be cardioprotective in an ischemia-reperfusion (IR) model; however, its role in IR ...
Jingwen Gao +2 more
doaj +1 more source
Seeing Invisible Oligomers: Rethinking α‐Synuclein Pathology Through Proximity Ligation Assay
Movement Disorders, EarlyView.Abstract Parkinson's disease (PD) and multiple system atrophy are defined by α‐synuclein (αSYN)‐positive inclusions – Lewy bodies (LBs) and glial cytoplasmic inclusions – yet mounting evidence indicates that these inclusions represent only a fraction of disease‐relevant pathology.
Hiroaki Sekiya +3 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi +12 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman +3 more
wiley +1 more source
daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival
eLife, 2017 daf-16/FoxO is required to survive starvation in Caenorhabditis elegans, but how daf-16IFoxO promotes starvation resistance is unclear. We show that daf-16/FoxO restructures carbohydrate metabolism by driving carbon flux through the glyoxylate shunt and ...
Jonathan D Hibshman +9 more
doaj +1 more source
Pest Management Science, EarlyView.Starvation stress significantly affected the growth and development of Hippodamia variegata. Combined transcriptome and metabolome analysis and RNA interference verification revealed that HvarAKR1B1 may be involved in the response of Hippodamia variegata to starvation stress.
Bing‐mei Song +5 more
wiley +1 more source
Pest Management Science, EarlyView.Queensland fruit fly pupae tolerate hypoxia up to 2 days without compromising quality. Prolonged hypoxia, especially at 25 °C, reduces emergence and flight ability. Storage at 18 °C is recommended. Abstract BACKGROUND The sterile insect technique is used to eradicate outbreaks of Queensland fruit fly (Q‐fly) Bactrocera tryoni (Froggatt) in fruit‐fly ...
Sushil K. Gaire +4 more
wiley +1 more source