Results 41 to 50 of about 55,407 (178)

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Phosphorylated Trehalose Suppresses the Denaturation of Myofibrillar Proteins in Peeled Shrimp (Litopenaeus vannamei) during Long-Term Frozen Storage

Foods, 2022
The protective effects of phosphorylated trehalose on the quality and characteristics of peeled shrimp (Litopenaeus vannamei) were determined. Quality changes in treated samples were evaluated by assessing the physicochemical properties of myofibrillar ...
Shanshan Shui, Huicheng Yang, Baiyi Lu, Bin Zhang   +3 more
doaj   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Dietary Trehalose Activates Autophagy Potentially Via MAPK Signaling Pathway to Alleviate Oxidative Stress Induced by Air Exposure Stress in Chinese Mitten Crab (Eriocheir sinensis)

Aquaculture Nutrition
Air exposure stress (AES) is a common stress faced by Chinese mitten crabs (Eriocheir sinensis) in aquaculture and transport. This study was designed to evaluate the levels of endogenous trehalose, oxidative stress, and autophagy in crabs subjected to ...
Anjun Xiang, Jiayi Chen, Jianyang Sun, Chengyi Weng, Yongxu Cheng, Xiaozhen Yang   +5 more
doaj   +1 more source

Against All Odds: Trehalose-6-Phosphate Synthase and Trehalase Genes in the Bdelloid Rotifer Adineta vaga Were Acquired by Horizontal Gene Transfer and Are Upregulated during Desiccation. [PDF]

PLoS ONE, 2015
The disaccharide sugar trehalose is essential for desiccation resistance in most metazoans that survive dryness; however, neither trehalose nor the enzymes involved in its metabolism have ever been detected in bdelloid rotifers despite their extreme ...
Boris Hespeels, Xiang Li, Jean-François Flot, Lise-Marie Pigneur, Jeremy Malaisse, Corinne Da Silva, Karine Van Doninck   +6 more
doaj   +1 more source

Clathrate hydrate crystallization

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Clathrate hydrate crystallization has been an area of interest to chemical engineers from the point of view of crystal structure, thermophysical properties, phase equilibria, kinetics, industrial applications, and environmental (climate change) implications.
Peter Englezos
wiley   +1 more source

Exogenous Carbohydrate Effects on Thermoadaptation and Thermostress in Ogataea parapolymorpha Under Different Carbon Sources

Fermentation
Thermotolerant methylotrophic yeast Ogataea parapolymorpha is a promising host for high-temperature bioprocesses, yet the effects of carbon source and exogenous carbohydrates on their heat response remain poorly understood.
Denis Atroshenko, Alexandra Roslova, Anastasia Yakobson, Diana Markova, Diana Golovina, Vladimir Tishkov   +5 more
doaj   +1 more source

Microbial ecological memory of recurrent drought enhances host stress tolerance through enrichment of plant‐beneficial bacteria

iMetaOmics, EarlyView.
Recurrent desiccation induced niche‐specific microbial ecological memory in the green part of Calohypnum plumiforme, marked by enrichment of plant‐beneficial bacteria, especially Methylobacterium and Sphingomonas, and functional shifts toward symbiosis and stress protection, potentially enhancing host tolerance within a “holobiont ecology memory ...
Chengguang Xing, Dandan Zhou, Dongwei Hou, Chunyi Lei, Zhiwei Liu, Jinhui Liu, Chaojian Hu, Jinye Liu, Shuzhen Huang, Yong Huo, Mingrui Zhou, Weiqiu Liu   +11 more
wiley   +1 more source