Results 41 to 50 of about 99,631 (278)

Versatile approach towards fully desymmetrized trehalose with a novel set of orthogonal protecting groups

Frontiers in Chemistry
Trehalose-containing glycans play an essential role in bacterial pathogenesis, host-pathogen interaction, and cell signaling. The investigation of trehalose uptake and metabolism in Mycobacteria using synthetic desymmetrized trehalose probes is an ...
Tomáš Vašíček, Benjamin Arensmeyer, Alessandro Monti, Alla Zamyatina   +3 more
doaj   +1 more source

Protective roles of trehalose in Pleurotus pulmonarius during heat stress response

Journal of Integrative Agriculture, 2019
High temperature is one of the major abiotic stresses that limit edible mushroom growth and development. The understanding of physiological alterations in response to heat stress and the corresponding mechanisms involved is vital for the breeding of heat-
Xiu-ming LIU, Xiang-li WU, Wei GAO, Ji-bin QU, Qiang CHEN, Chen-yang HUANG, Jin-xia ZHANG   +6 more
doaj   +1 more source

Counteraction of Trehalose on N, N-Dimethylformamide-Induced Candida rugosa Lipase Denaturation: Spectroscopic Insight and Molecular Dynamic Simulation. [PDF]

PLoS ONE, 2016
Candida rugosa lipase (CRL) has been widely used as a biocatalyst for non-aqueous synthesis in biotechnological applications, which, however, often suffers significant loss of activity in organic solvent.
Xin Yang, Ling Jiang, Yigang Jia, Yi Hu, Qing Xu, Xian Xu, He Huang   +6 more
doaj   +1 more source

SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy [PDF]

, 2016
Trehalose is a disaccharide demonstrated to mitigate disease burden in multiple murine neurodegenerative models. We recently revealed that trehalose rapidly induces hepatic autophagy and abrogates hepatic steatosis by inhibiting hexose transport via the ...
Beatty, Wandy L, Crowley, Jan R, DeBosch, Brian J, Heitmeier, Monique R, Higgins, Cassandra B, Hruz, Paul W, Hyrc, Krzysztof L, Kraft, Thomas E, Mayer, Allyson L, Qian, Xia, Yarasheski, Kevin E   +10 more
core   +3 more sources

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria [PDF]

, 2020
The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist ...
Fullam, Elizabeth, Furze, Christopher M., Guy, Collette S., Parker, Hadyn, Tomás, Ruben M. F.   +4 more
core   +1 more source

The role of trehalose metabolism in plant stress tolerance

Journal of Advanced Research
Background: Trehalose is a nonreducing disaccharide containing two glucose molecules linked through an α,α-1,1-glycosidic bond. This unique chemical structure causes trehalose levels to fluctuate significantly in plants under stress, where it functions ...
Tong-Ju Eh, Yaxuan Jiang, Mingquan Jiang, Jianxin Li, Pei Lei, Ximei Ji, Hyon-Il Kim, Xiyang Zhao, Fanjuan Meng   +8 more
doaj   +1 more source

Trehalose maintains vitality of mouse epididymal epithelial cells and mediates gene transfer. [PDF]

PLoS ONE, 2014
In the present study, trehalose was utilized to improve primary culture of mouse epididymal epithelial cells in vitro, and to enhance naked DNA delivery in epididymis in vivo.
Bin Qu, Yihua Gu, Jian Shen, Jinzhou Qin, Jianqiang Bao, Yuan Hu, Wenxian Zeng, Wuzi Dong   +7 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A Snapshot of the Trehalose Pathway During Seed Imbibition in Medicago truncatula Reveals Temporal- and Stress-Dependent Shifts in Gene Expression Patterns Associated With Metabolite Changes

Frontiers in Plant Science, 2019
Trehalose, a non-reducing disaccharide with multiple functions, among which source of energy and carbon, stress protectant, and signaling molecule, has been mainly studied in relation to plant development and response to stress.
Anca Macovei, Andrea Pagano, Michela Cappuccio, Michela Cappuccio, Lucia Gallotti, Daniele Dondi, Susana De Sousa Araujo, Pedro Fevereiro, Pedro Fevereiro, Alma Balestrazzi   +9 more
doaj   +1 more source

Trehalose Metabolism and Signaling

Annual Review of Plant Biology, 2008
Trehalose metabolism and signaling is an area of emerging significance. In less than a decade our views on the importance of trehalose metabolism and its role in plants have gone through something of a revolution. An obscure curiosity has become an indispensable regulatory system.
Paul, M. J., Primavesi, L. F., Jhurreea, D., Zhang, Y.   +3 more
openaire   +2 more sources