Diversity of Treponema denticola and Other Oral Treponeme Lineages in Subjects with Periodontitis and Gingivitis [PDF]
Microbiology Spectrum, 2021 More than 75 species/species-level phylotypes belonging to the genus Treponema inhabit the human oral cavity. Treponema denticola is commonly associated with periodontal disease, but the etiological roles and ecological distributions of other oral ...
Huihui Zeng +4 more
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Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 The periodontal complex consists of the periodontal ligament (PDL), alveolar bone, and cementum, which work together to turn mechanical load into biological responses that are responsible for maintaining a homeostatic environment.
Erin Trent Malone +10 more
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Treponema denticola Induces Neuronal Apoptosis by Promoting Amyloid-β Accumulation in Mice [PDF]
Pathogens, 2022 Background: Neuronal apoptosis is a major contributor to Alzheimer’s disease (AD). Periodontitis is a significant risk factor for AD. The periodontal pathogens Porphyromonas gingivalis and Treponema denticola have been shown to initiate the hallmark ...
Linrui Wu +6 more
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Characterization of clustered bacteriocin-type signal domain protein genes in Treponema denticola [PDF]
Frontiers in Dental MedicineBackgroundPeriodontitis is caused by the dysbiosis of subgingival plaque, and Treponema denticola is the pathogen associated with this disease. Bacteriocins are involved in interbacterial competition during dysbiosis.
Tomoyuki Nukaga +6 more
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Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis [PDF]
Journal of Oral Microbiology, 2014 Treponema denticola is an important periodontal pathogen capable of tissue invasion. Its chymotrypsin-like proteinase (CTLP) can degrade a number of basement membrane components in vitro, thus suggesting a contribution to tissue invasion by the ...
Emilia Marttila +7 more
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The unique histidine kinase, AtcS, regulates motility and pathogenicity of the periodontal pathobiont, Treponema denticola [PDF]
Infection and ImmunityTreponema denticola is an obligate colonizer of the human gingival crevice and, along with other pathobionts, is highly associated with the development of periodontal disease.
Doaa N. Abdallah +6 more
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Metabolic cooperativity between Porphyromonas gingivalis and Treponema denticola [PDF]
Journal of Oral Microbiology, 2020 Background Porphyromonas gingivalis and Treponema denticola are proteolytic periodontopathogens that co-localize in polymicrobial subgingival plaque biofilms, display in vitro growth symbiosis and synergistic virulence in animal models of disease. These
Lin Xin Kin +5 more
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Purification of Native Dentilisin Complex from Treponema denticola by Preparative Continuous Polyacrylamide Gel Electrophoresis and Functional Analysis by Gelatin Zymography [PDF]
Bio-ProtocolPeriodontal disease is characterized by the destruction of the hard and soft tissues comprising the periodontium. This destruction translates to a degradation of the extracellular matrices (ECM), mediated by bacterial proteases, host-derived matrix ...
Pachiyappan Kamarajan +8 more
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The potential role of genus Treponema in carcinogenesis with a focus on oral squamous cell carcinoma: a scoping review of the evidence [PDF]
BMC Oral HealthBackground Current concepts suggest that a dysbiotic environment can promote ‘oral carcinomas.’ Microbiome studies on the oral cavity indicate changes in bacterial disposition in this condition.
Pratibha Gopalkrishna +6 more
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The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis [PDF]
Frontiers in Cellular and Infection Microbiology, 2019 Chronic periodontitis has a polymicrobial biofilm etiology and interactions between key oral bacterial species, such as Porphyromonas gingivalis and Treponema denticola contribute to disease progression. P. gingivalis and T. denticola are co-localized in
Hong Min Ng +8 more
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