Results 171 to 180 of about 7,910 (222)

Treponema denticola Promotes OSCC Development via the TGF-β Signaling Pathway

Journal of dentistry research, 2022
Numerous studies have demonstrated an association between periodontitis and oral squamous cell carcinoma (OSCC), and periodontal pathogens such as Treponema denticola are implicated in the pathogenesis of OSCC.
R. Peng, Y. Sun, X.D. Zhou, S.Y. Liu, Q. Han, L. Cheng, X. Peng   +6 more
semanticscholar   +1 more source

Treponema denticola Induces Alzheimer-Like Tau Hyperphosphorylation by Activating Hippocampal Neuroinflammation in Mice

Journal of dentistry research, 2022
Alzheimer’s disease (AD) is the most common type of dementia. Tau hyperphosphorylation and amyloid β (Aβ) deposition are the key pathological hallmarks of AD. Recent studies have shown that periodontitis is a significant risk factor for AD.
Z. Tang, X. Cheng, X. Su, L. Wu, Q. Cai, H. Wu   +5 more
semanticscholar   +1 more source

Activation of Complement by Treponema denticola

Journal of Dental Research, 1991
Oral spirochetes have been shown to be associated with periodontal diseases and are present in increased numbers in lesions of greater severity. In this study, the interaction of Treponema denticola with human complement, a major antibacterial defense system, was examined. For each of two strains of T.
H A, Schenkein, C R, Berry
openaire   +2 more sources

Major proteins and antigens of Treponema denticola

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009
Treponema denticola is a Gram-negative, motile, asaccharolytic, anaerobic spirochaete which along with Porphyromonas gingivalis and Tannerella forsythia has been shown to form a bacterial consortium called the Red Complex that is strongly associated with the clinical progression of chronic periodontitis. T.
Paul D, Veith, Stuart G, Dashper, Neil M, O'Brien-Simpson, Rita A, Paolini, Rebecca, Orth, Katrina A, Walsh, Eric C, Reynolds   +6 more
openaire   +2 more sources

Locomotory characteristics of Treponema denticola

Canadian Journal of Microbiology, 1988
Locomotion of pathogenic spirochetes has been suggested as a virulence factor in their pathogenesis. Little is known of the locomotory characteristics of oral anaerobic spirochetes. We have determined the optimal conditions for motility of seven strains of Treponema denticola in menstrua of different viscosities. The viscosity for optimum motility for
F, Pietrantonio, P B, Noble, R, Amsel, E C, Chan   +3 more
openaire   +2 more sources

Genetic Manipulation of Treponema denticola

Current Protocols in Microbiology, 2006
AbstractThe oral anaerobic spirochete, Treponema denticola, has been implicated in the etiology of human periodontal diseases; however, the molecular basis for the virulence of these organisms is still unclear. Potential pathogenic factors expressed by T. denticola have recently begun to be identified through the development of gene transfer approaches
Howard K, Kuramitsu, Bo, Chi, Akihiko, Ikegami   +2 more
openaire   +2 more sources

Oxygen metabolism by Treponema denticola

Oral Microbiology and Immunology, 1999
Treponema denticola strains ATCC 35405 and ASLM were found to have moderately active oxygen metabolism and consumed some 0.46 μmol O2/h/mg cell protein in anaerobic growth medium or about ten times this amount in aerobic medium. There appeared to be no differences between the two strains in their oxidative metabolism.
C E, Caldwell, R E, Marquis
openaire   +2 more sources

A Study of the Acid Phosphatase of Treponema denticola

Zentralblatt für Bakteriologie, 1990
This study describes some of the properties of the acid phosphatase of the potential periodontopathogen Treponema denticola. The highest enzyme activity was found in 87 h old cells. Two optimum pHs for enzyme activity were detected, one at pH 4.8 and another at pH 6.2. Divalent cations did not influence the acid phosphatase of T. denticola. The anion F-
C A, Norton Hughes, W W, Yotis
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Adherence of Treponema denticola to Modified Hydroxyapatite

Journal of Dental Research, 1987
Small samples of hydroxyapatite (HA) beads were coated with 10 μL of either saliva, serum, human crevicular fluid, or a preparation of lysosomal enzymes from human polymorphonuclear leucocytes (PMN), before being added to suspensions of Treponema denticola. The beads were then observed with the scanning electron microscope. Abundant T.
G, Cimasoni, B C, McBride
openaire   +2 more sources

Antigenic and Structural Analysis of Treponema denticola

Microbiology, 1989
Polypeptide and Western immunoblot profiles of subcellular fractions of Treponema denticola ATCC 33520 have been determined by SDS-PAGE of Triton X-100-soluble and -insoluble fractions, a lipopolysaccharide-enriched fraction and purified flagella. Major Triton X-100-soluble polypeptides of 72, 68, 54 and 52 kDa were detected.
A, Cockayne, R, Sanger, A, Ivic, R A, Strugnell, J H, MacDougall, R R, Russell, C W, Penn   +6 more
openaire   +2 more sources