Results 41 to 50 of about 13,053 (160)

Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation [PDF]

, 2019
Neurodegenerative diseases are characterized by a progressive loss of neurons that leads to a broad range of disabilities, including severe cognitive decline and motor impairment, for which there are no effective therapies.
Codocedo, Juan F., Landreth, Gary E., Moutinho, Miguel, Puntambekar, Shweta S.   +3 more
core   +1 more source

Wound, pressure ulcer, and burn guidelines (2023)―4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers, third edition

The Journal of Dermatology, EarlyView.
Yoshihide Asano, Jun Asai, Takayuki Ishii, Yohei Iwata, Masanari Kodera, Chie Miyabe, Akihiko Uchiyama, Youichi Ogawa, Ken Okamura, Mari Kishibe, Yuta Koike, Yorihisa Kotobuki, Noriki Fujimoto, Takuya Miyagi, Yukie Yamaguchi, Ayumi Yoshizaki, Reiko Omori, Takeshi Nakanishi, Hiroshi Fujiwara, Takeo Maekawa, Sei‐ichiro Motegi, Yuichiro Yoshino, Minoru Hasegawa, Manabu Fujimoto, Takao Tachibana, Wound, Pressure Ulcer, and Burn Guidelines Drafting Committee (connective tissue disease/vasculitis group)   +27 more
wiley   +1 more source

Clinical Features and Current Therapeutic Approaches to Monilethrix: A Systematic Review

Pediatric Dermatology, EarlyView.
ABSTRACT Monilethrix is a rare congenital hair disorder characterized by fragile, beaded hair shafts due to mutations in various keratin or desmoglein 4 genes. A systematic review of 24 studies (16 pediatric only, 3 mixed adult and pediatric, 3 adult only, and 2 unspecified) evaluating various treatment modalities identified topical and oral minoxidil ...
Adam C. Yu, Dana Koroluk, Fatmah Alzahrani   +2 more
wiley   +1 more source

Preparation and Evaluation of Tretinoin Microemulsion Based on Pseudo-Ternary Phase Diagram [PDF]

, 2012
Purpose: The aim of the present research was to formulate a transparent microemolsion as a topical delivery system for tretinoin for the treatment of acne.
Anayatollah Salimi, Eskandar Moghimipour, Fatemeh Leis   +2 more
core  

A rational pharmacotherapeutic study of comparative safety among topical anti-acne 1% nadifloxacin monotherapy, 0.1% adapalene monotherapy, 0.025% tretinoin monotherapy, 1% nadifloxacin and 0.1% adapalene combination therapy and 1% nadifloxacin and 0.025% tretinoin combination therapy, in mild to moderate acne vulgaris, in tertiary care hospitals [PDF]

, 2019
Background: Topical adapalene and tretinoin, are comedolytic, anti-comedogenic and anti-inflammatory, on RAR (α, β, γ) receptors binding. Adapalene enables quicker follicular penetration, by lesser anti-AP-1 (c-Jun, c-Fos) and no CRBPII mRNA actions ...
Hazra, Moumita
core   +2 more sources

Efficacy of Calcipotriol/Betamethasone Ointment in Facial Discoid Dermatosis

JEADV Clinical Practice, Volume 4, Issue 2, Page 544-551, June 2025.
ABSTRACT Facial Discoid Dermatosis (FDD) is a rare chronic skin condition characterised by persistent, annular erythematous and desquamative papules on the face. Its aetiology is unclear, making differential diagnosis challenging. Key clinical features include pink‐orange, minimally scaling lesions limited to the face, sudden onset with long‐term ...
Alberto Murtas, Cristina Mugheddu, Luca Pilloni, Franco Rongioletti, Laura Atzori   +4 more
wiley   +1 more source

SIMULTANEOUS IDENTIFICATION AND QUANTIFICATION OF HYDROQUINONE, TRETINOIN AND BETAMETHASONE IN COSMETIC PRODUCTS BY ISOCRATIC REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY [PDF]

, 2019
Objective: The objective of this study was to obtain a simple and selective analysis method for determination of hydroquinone, tretinoin and betamethasone in whitening creams using reversed phase high-performance liquid chromatography (HPLC).
harahap, yahdiana, harmita, HUTABALIAN, HANA LILI NATASYA, maggadani, baitha PALANGGATAN   +3 more
core   +3 more sources

Alcohol Dehydrogenase 4‐Mediated Retinol Metabolism Inhibits Hepatocellular Carcinoma Progression Through Inhibiting the Wnt/β‐Catenin Pathway

MedComm – Oncology, Volume 4, Issue 2, June 2025.
The downregulation of ADH4 expression induces hepatocyte apoptosis, thereby contributing to liver fibrosis and the initiation of hepatocellular carcinoma (HCC). Moreover, sustained suppression of ADH4 in HCC cells disrupts retinoic acid synthesis, leading to reduced expression of the Wnt/β‐catenin signaling inhibitor WIF‐1 via RARs/RXRs‐mediated ...
Jiaying Li, Mingshu Gao, Yanan Zhang, Dawen Liao, Feng Zhou, Zhaohui Zhang, Lele Ji, Yilin Zhao, Qichao Huang, Qian Bi, Nan Wang   +10 more
wiley   +1 more source

A Pilot Trial Of Pioglitazone Hcl And Tretinoin In Als: Cerebrospinal Fluid Biomarkers To Monitor Drug Efficacy And Predict Rate Of Disease Progression [PDF]

, 2012
Objectives. To determine if therapy with pioglitazone HCl and tretinoin could slow disease progression in patients with ALS. Levels of tau and pNFH in the cerebrospinal fluid were measured to see if they could serve as prognostic indicators. Methods.
Bowser, Robert, Gately, Stephen, Hank, Nicole C., Keuren-Jensen, Kendall Van, Levine, Todd D., Saperstein, David S., Stephan, Dietrich   +6 more
core   +3 more sources

Alopecia Areata: Pathogenesis, Diagnosis, and Therapies

MedComm, Volume 6, Issue 5, May 2025.
This review probed into the immune factors in the pathogenesis of AA, focusing on the small molecule drugs and biologics for the treatment of AA, and anticipated the research direction in terms of the pathogenesis and targeted therapy of AA. It aims to emphasize the necessity for further exploration of its immunological pathogenesis and therapeutic ...
Tianyou Ma, Tingrui Zhang, Fengze Miao, Jun Liu, Quangang Zhu, Zhongjian Chen, Zongguang Tai, Zhigao He   +7 more
wiley   +1 more source