Results 111 to 120 of about 20,759 (251)

Signaling Pathway–Biomarker Coupling for Precision Therapy in Rheumatoid Arthritis: Mechanistic Insights, Translational Bottlenecks, and Emerging Strategies

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease. Despite advances in targeted therapies, significant interindividual variability in treatment response and a lack of precise predictive tools limit the achievement of treat‐to‐target goals.
Shijie Meng, Feng Xing, Yuyang Luo, Jianxin Li, Yingchen Ni, Fengyuan Zhang, Hua Xu, Youhua Wang, Weidong Zhang   +8 more
wiley   +1 more source

Circulating tRF-Gly-GCC as a biomarker for colorectal cancer and Crohn's disease activity. [PDF]

Sci Rep
Salah S, Dwedar F, Nassra R, Mahmoud A, Zahra M.   +4 more
europepmc   +1 more source

The impact of temporal synchronisation imprecision on TRF analyses

Journal of Neuroscience Methods, 2023
Sara, Carta, Anthony M A, Mangiacotti, Alejandro Lopez, Valdes, Richard B, Reilly, Fabia, Franco, Giovanni M, Di Liberto   +5 more
openaire   +2 more sources

G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation

Advanced Science, Volume 13, Issue 45, 13 August 2026.
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang, Qingqing Xu, Yuxin Zhang, Fang Liu, Guangchao Sui, Dangdang Li   +5 more
wiley   +1 more source

tRF-1-ArgTCG-1-1 promotes renal fibrosis by regulating β-catenin. [PDF]

Ren Fail
Jin L, Wang C, Yan Y, Chen Y, Xiao Z, Wang Y, Shi Y, Fu C, Cao Y.   +8 more
europepmc   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, Volume 13, Issue 47, 24 August 2026.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Distinct fingerprints of tRNA-derived small non-coding RNA in animal models of neurodegeneration

Disease Models & Mechanisms
Sharada Baindoor, Hesham A. Y. Gibriel, Morten T. Venø, Junyi Su, Elena Perez Morrissey, Elisabeth Jirström, Ina Woods, Aidan Kenny, Mariana Alves, Luise Halang, Paola Fabbrizio, Maria Bilen, Tobias Engel, Marion C. Hogg, Caterina Bendotti, Giovanni Nardo, Ruth S. Slack, Jørgen Kjems, Jochen H. M. Prehn   +18 more
doaj   +1 more source

Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle. [PDF]

Function (Oxf)
Davis XC, McCoin CS, Salathe SF, Franczak E, Allen JA, Queathem ED, Fulghum KL, Puchalska P, Crawford PA, Thyfault JP, Morris EM.   +10 more
europepmc   +1 more source

ParamNet: A Physics‐Guided Deep Learning Framework for Intelligent Self‐Inversion of Vacuum Optical Levitation Systems

Advanced Intelligent Systems, Volume 8, Issue 8, August 2026.
A physics‐guided deep learning framework, ParamNet, is introduced for the intelligent self‐inversion of vacuum optical tweezers. By fuzing dual‐branch time–frequency features with physical dynamical constraints, it achieves high‐accuracy calibration of trap parameters from short‐window, low‐frequency trajectories, outperforming traditional methods ...
Qi Zheng, Wenfeng Fan, Feng Li, Jian Wu, Wei Quan   +4 more
wiley   +1 more source

Time-restricted feeding enhances cross-tissue temporal coordination of mitochondrial-associated transcripts. [PDF]

iScience
Sarver DC, Maddahi Y, Colwell CS, Lusis AJ.   +3 more
europepmc   +1 more source