Role of tRNA derived fragments in renal ischemia–reperfusion injury [PDF]
Renal Failure, 2022 Background Ischemia–reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI). tRNA derived fragments (tRFs/tiRNAs) are groups of small noncoding RNAs derived from tRNAs.
, Hao Zhang, Shiqi Tang
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Screening and Comprehensive Analysis of Cancer-Associated tRNA-Derived Fragments [PDF]
Frontiers in Genetics, 2022 tRNA-derived fragments (tRFs) constitute a novel class of small non-coding RNA cleaved from tRNAs. In recent years, researches have shown the regulatory roles of a few tRFs in cancers, illuminating a new direction for tRF-centric cancer researches ...
Yuan Zhou, Yiran Zhou, Qinghua Cui
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Differentially expressed tRNA-derived fragments and their roles in primary cardiomyocytes stimulated by high glucose [PDF]
Frontiers in Endocrinology, 2023 Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus that can cause malignant arrhythmia and sudden death and is associated with cardiomyocyte dysfunction induced by hyperglycemia.
Lihong Wang, Ruxin Wang, Wang Ruxin
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Emerging roles of tRNA-derived fragments in cancer [PDF]
Molecular Cancer, 2023 tRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to the identification of increasing number of ...
Min Fu +7 more
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Mitochondrial tRNA-Derived Fragments and Their Contribution to Gene Expression Regulation [PDF]
Frontiers in Physiology, 2021 Mutations in human mitochondrial tRNAs (mt-tRNAs) are responsible for several and sometimes severe clinical phenotypes, classified among mitochondrial diseases.
Athanasios-Nasir Shaukat +3 more
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Role of tRNA-Derived Fragments in Protozoan Parasite Biology [PDF]
CellstRNA molecules are among the most fundamental and evolutionarily conserved RNA types, primarily facilitating the translation of genetic information from mRNA into proteins.
Manu Sharma, Upinder Singh
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Menstrual cycle-dependent expression of tRNA-derived fragments in healthy human endometrium and uterine fluid-derived extracellular vesicles [PDF]
BMC GenomicsThe human endometrium undergoes dynamic cyclical remodeling across the menstrual cycle to establish receptivity for embryo implantation. While microRNAs are established regulators of endometrial function and embryo–maternal communication, the ...
Apostol Apostolov +8 more
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The role and mechanism of action of tRNA-derived fragments in the diagnosis and treatment of malignant tumors [PDF]
Cell Communication and Signaling, 2023 Cancer is a leading cause of morbidity and death worldwide. While various factors are established as causing malignant tumors, the mechanisms underlying cancer development remain poorly understood.
Mengdan Gong +3 more
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The widespread occurrence of tRNA‐derived fragments in Saccharomyces cerevisiae
FEBS Open Bio, 2016 Short RNAs derived from the cleavage of tRNA molecules are observed in most organisms. Their occurrence seems to be induced by stress conditions, but still little is known about their biogenesis and functions.
Piotr Machtel +2 more
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Differential prognostic roles and clinical implications of mitochondrial and genomic tRNA-derived fragments in colorectal liver metastases [PDF]
Journal of Translational MedicineBackground Colorectal liver metastases (CRLM) are the leading cause of colorectal cancer (CRC)-related mortality. Transfer RNA-derived fragments (tRFs), a novel class of small non-coding RNAs (sncRNA), regulate gene expression, stress response, and ...
Rebecca Zirnbauer +11 more
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