Results 1 to 10 of about 1,325 (100)

tsRNA-Ala-3–0030 drives ovarian cancer progression by suppressing ZNF70 [PDF]

Frontiers in Oncology
Globally, ovarian cancer remains a leading cause of gynecologic cancer death. This poor prognosis is primarily attributed to advanced disease at diagnosis, a high propensity for recurrence, and the inadequate therapeutic efficacy of current standard ...
Liang Hongwei
exaly   +4 more sources

tsRNA-08614 inhibits glycolysis and histone lactylation by ALDH1A3 to confer oxaliplatin sensitivity in colorectal cancer [PDF]

Translational Oncology
Background: Enhanced glycolysis contributes to the chemotherapy resistance of colorectal cancer (CRC). However, whether tRNA-derived small RNAs (tsRNAs) regulate CRC oxaliplatin sensitivity through glycolysis-mediated histone lactylation remains unclear.
Yiyang Zhang
exaly   +4 more sources

tsRNA-3025a Impairs Mitochondrial Function and Autophagy to Inhibit Myocardial Regeneration and Repair Following Ischemia–Reperfusion Injury [PDF]

Journal of Cardiovascular Development and Disease
Myocardial ischemia–reperfusion (I/R) injury is a frequent complication of acute myocardial infarction (AMI), yet clinical biomarkers and targets remain limited.
Zehao Feng, Xing Li, Ai Zhou, Han Zhang, Kaixuan Tang, Yumo Yang, Ying Chen, Li Zhang, Lingmei Qian   +8 more
doaj   +2 more sources

A cholesterol-responsive hepatic tRNA-derived small RNA regulates cholesterol homeostasis and atherosclerosis development [PDF]

Nature Communications
Transfer RNA-derived small RNAs (tsRNAs) have emerged as crucial players in diverse biological processes. Yet, their involvement in lipid metabolism and cardiovascular disease remains elusive.
Xiuchun Li, Rebecca Hernandez, Xudong Zhang, Sijie Tang, Xiaohong Yuan, Jing Wu, Kathy Pham, Hukam C. Rawal, Erica C. Heinrich, Shenglong Zhang, Qi Chen, Tong Zhou, Changcheng Zhou   +12 more
doaj   +2 more sources

Inhibition of ferroptosis alleviates chronic unpredictable mild stress-induced depression in mice via tsRNA-3029b

Brain Research Bulletin, 2023
Depression is a common mental illness. Ferroptosis is a form of cell death that may be responsible for neurological disease, but the role of ferroptosis in depression remains unclear.
Chong Tang, Junlong Guo, Enze Li
exaly   +3 more sources

tsRNA-3040b accumulates R-loop to regulate Trim35 transcription, which leads to disordered glycolysis and promotes PAECs proliferation [PDF]

Cellular & Molecular Biology Letters
Background Hypoxia significantly influences the development of pulmonary hypertension (PH). However, the role of transfer RNA-derived small RNAs (tsRNAs) produced by nuclease cleavage on PH, particularly their impact on the proliferation of pulmonary ...
Xu Wang, Songyue Li, Jianli Hou, Shukun Cao, Yibin Zhang, Jingya Zhang, Xinru Wang, Xinyue Song, Ya Xu, Jing Qi, Yan Xing, Xiaodong Zheng   +11 more
doaj   +2 more sources

Functional and clinical validation of tsRNA-defined molecular subtypes guides precision therapy in gastric cancer [PDF]

Frontiers in Immunology
IntroductionGastric cancer (GC) is a highly heterogeneous malignancy with poor prognosis, underscoring the urgent need for reliable biomarkers to guide precise stratification and therapy. Transfer RNA-derived small RNAs (tsRNAs) have emerged as potential
Ye Tian, Ye Tian, Ye Tian, Ye Tian, Ye Tian, Xin Hu, Xin Hu, Xin Hu, Xin Hu, Yuan Liu, Yuan Liu, Wenqi Wu, Wenqi Wu, Wenqi Wu, Yanxin Yao, Yanxin Yao, Huahuan Liu, Huahuan Liu, Wei Wang, Wei Wang, Hongji Dai, Hongji Dai, Yubei Huang, Yubei Huang, Changyu Sun, Changyu Sun, Changyu Sun, Yan Cui, Yan Cui, Yan Cui, Zun Li, Zun Li, Xiangnan Zhang, Xiangnan Zhang, Liqing Jia, Liqing Jia, Fubing Wang, Fubing Wang, Fengju Song, Fengju Song, Kexin Chen, Kexin Chen, Yuan Pan, Yuan Pan, Yuan Pan, Ben Liu, Ben Liu   +46 more
doaj   +2 more sources

tsRNA-25172 inhibits aldosterone secretion in aldosterone-producing adenomas [PDF]

Endocrine Connections
The pathophysiology of aldosterone-producing adenomas (APAs) is characterized by aldosterone hypersecretion. Transfer RNA-derived small RNAs (tsRNAs) are novel non-coding RNAs, which are involved in multiple biological processes.
Qiwei Fan, Liqing Liu, Zhihua Jiang, Shanshan Feng, Jiancheng Wang, Jianrong Chen   +5 more
doaj   +2 more sources

Transfer RNA-derived small RNAs (tsRNAs) in Alzheimer’s disease: emerging mechanisms and diagnostic potential [PDF]

Medical Review
Transfer RNA-derived small RNAs (tsRNAs), a class of non-coding RNAs derived from precursor or mature tRNAs, are now recognized as critical regulators in response to cellular stress.
Zhang Juan, Han Jialuo, Liu Qiang
doaj   +2 more sources

Integrated transcriptomic analysis identifies tsRNA–mRNA regulatory axis in asthma pathogenesis [PDF]

World Allergy Organization Journal
Background: Asthma is a complex respiratory disorder with incompletely understood molecular mechanisms. tRNA-derived small RNAs (tsRNAs), a newly discovered class of non-coding RNAs, have been implicated in various diseases, but their role in asthma ...
Ying Zhou, M.S., Hang Lin, M.D., Dongmei Zhou, M.S., Xinhui Gong, B.S., Ximeng Ma, B.S., Lei Shi, M.S., Yubao Cui, Ph.D.   +6 more
doaj   +2 more sources